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4'-Trifluoromethyl-biphenyl-3-carbaldehyde is an organic chemical compound that belongs to the class of biphenyls and related compounds. Its systematic name is (4'-(Trifluoromethyl)biphenyl-3-yl)methanal. It is characterized by having a biphenyl backbone where one of the aromatic rings contains a trifluoromethyl (-CF3) substituent at the fourth position and a formyl group (carbaldehyde -CHO) at the third position. Its exact physical properties such as molecular weight, boiling point, and melting point can vary depending on the detailed molecular structure.

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  • 343604-24-0 Structure
  • Basic information

    1. Product Name: 4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE
    2. Synonyms: 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-3-CARBOXALDEHYDE;4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE;3-[4-(TRIFLUOROMETHYL)PHENYL]BENZALDEHYDE;3-(2-Nitrophenyl)benzaldehyde;4'-Trifluoromethyl-biphenyl-3-carbaldehyde;Zinc02382442;4'-(TrifluoroMethyl)biphenyl-3-carboxaldehyde, 95%;3-[4-(Trifluoromethyl)phenyl]benzaldehyde, 4-(3-Formylphenyl)benzotrifluoride
    3. CAS NO:343604-24-0
    4. Molecular Formula: C14H9F3O
    5. Molecular Weight: 250.22
    6. EINECS: 604-604-1
    7. Product Categories: Biphenyl & Diphenyl ether
    8. Mol File: 343604-24-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 106°C/1.07mm
    3. Flash Point: 158.1°C
    4. Appearance: /
    5. Density: 1.251g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.539
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(343604-24-0)
    12. EPA Substance Registry System: 4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(343604-24-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 43
    3. Safety Statements: 36/37
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 343604-24-0(Hazardous Substances Data)

343604-24-0 Usage

Uses

Used in Organic Synthesis:
4'-Trifluoromethyl-biphenyl-3-carbaldehyde is used as a chemical intermediate for the synthesis of other organic compounds. Its unique structure with a trifluoromethyl group and a formyl group allows it to be a valuable building block in the creation of various complex molecules.
However, it is important to note that details about its toxicity, safety measures, potential uses, and environmental impact are not readily available, implying that it is not commonly used or researched. Further investigation and research would be necessary to fully understand its applications and safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 343604-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,6,0 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 343604-24:
(8*3)+(7*4)+(6*3)+(5*6)+(4*0)+(3*4)+(2*2)+(1*4)=120
120 % 10 = 0
So 343604-24-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H9F3O/c15-14(16,17)13-6-4-11(5-7-13)12-3-1-2-10(8-12)9-18/h1-9H

343604-24-0 Well-known Company Product Price

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  • Alfa Aesar

  • (H57011)  4'-(Trifluoromethyl)biphenyl-3-carboxaldehyde, 95%   

  • 343604-24-0

  • 250mg

  • 273.0CNY

  • Detail
  • Alfa Aesar

  • (H57011)  4'-(Trifluoromethyl)biphenyl-3-carboxaldehyde, 95%   

  • 343604-24-0

  • 1g

  • 874.0CNY

  • Detail

343604-24-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[4-(trifluoromethyl)phenyl]benzaldehyde

1.2 Other means of identification

Product number -
Other names 4'-trifluoromethylbiphenyl-3-carboxaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:343604-24-0 SDS

343604-24-0Relevant articles and documents

Microwave-assisted organic acid-base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides

Shi, Yi,Li, Siqi,Lu, Yang,Zhao, Zizhen,Li, Pingfan,Xu, Jiaxi

supporting information, p. 2131 - 2134 (2020/02/27)

A novel organic acid-base-co-catalyzed conversion of styrylepoxides into [1,1′-biaryl]-3-carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1′-biaryl]-3-carbaldehydes.

One-Pot Tandem Photoredox and Cross-Coupling Catalysis with a Single Palladium Carbodicarbene Complex

Hsu, Yu-Cheng,Wang, Vincent C.-C.,Au-Yeung, Ka-Chun,Tsai, Chung-Yu,Chang, Chun-Chi,Lin, Bo-Chao,Chan, Yi-Tsu,Hsu, Chao-Ping,Yap, Glenn P. A.,Jurca, Titel,Ong, Tiow-Gan

supporting information, p. 4622 - 4626 (2018/03/21)

The combination of conventional transition-metal-catalyzed coupling (2 e? process) and photoredox catalysis (1 e? process) has emerged as a powerful approach to catalyze difficult cross-coupling reactions under mild reaction conditions. Reported is a palladium carbodicarbene (CDC) complex that mediates both a Suzuki–Miyaura coupling and photoredox catalysis for C?N bond formation upon visible-light irradiation. These two catalytic pathways can be combined to promote both conventional transition-metal-catalyzed coupling and photoredox catalysis to mediate C?H arylation under ambient conditions with a single catalyst in an efficient one-pot process.

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Carrasco, Marta P.,Machado, Marta,Gon?alves, Lídia,Sharma, Moni,Gut, Jiri,Lukens, Amanda K.,Wirth, Dyann F.,André, Vania,Duarte, Maria Teresa,Guedes, Rita C.,dos Santos, Daniel J. V. A.,Rosenthal, Philip J.,Mazitschek, Ralph,Prudêncio, Miguel,Moreira, Rui

supporting information, p. 2194 - 2204 (2016/10/19)

The potential of azaaurones as dual-stage antimalarial agents was investigated by assessing the effect of a small library of azaaurones on the inhibition of liver and intraerythrocytic lifecycle stages of the malaria parasite. The whole series was screened against the blood stage of a chloroquine-resistant Plasmodium falciparum strain and the liver stage of P. berghei, yielding compounds with dual-stage activity and sub-micromolar potency against erythrocytic parasites. Studies with genetically modified parasites, using a phenotypic assay based on the P. falciparum Dd2-ScDHODH line, which expresses yeast dihydroorotate dehydrogenase (DHODH), showed that one of the azaaurone derivatives has the potential to inhibit the parasite mitochondrial electron-transport chain. The global urgency in finding new therapies for malaria, especially against the underexplored liver stage, associated with chemical tractability of azaaurones, warrants further development of this chemotype. Overall, these results emphasize the azaaurone chemotype as a promising scaffold for dual-stage antimalarials.

Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate addition of terminal alkyne to α,β-unsaturated thioamide

Yazaki, Ryo,Kumagai, Naoya,Shibasaki, Masakatsu

supporting information; experimental part, p. 952 - 955 (2011/04/25)

A concise enantioselective synthetic route to a potent GPR40 agonist AMG 837 is described. The crucial catalytic asymmetric conjugate addition of terminal alkyne was promoted by a soft Lewis acid/hard Bronsted base cooperative catalyst, allowing efficient

GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES

-

Page/Page column 45-46, (2010/02/15)

The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by arylthienylacryloyl-aminobenzophenones

Mitsch, Andreas,Altenkaemper, Mirko,Sattler, Isabel,Schlitzer, Martin

, p. 9 - 17 (2007/10/03)

We recently described two novel aryl binding sites of farnesyltransferase. The 4- and 5-arylsubstituted thienylacryloyl moieties turned out as appropriate substituents for our benzophenone-based AAX-peptidomimetic capable for occupying the far aryl binding site.

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Wiesner,Mitsch,Altenkaemper,Ortmann,Jomaa,Schlitzer, Martin

, p. 854 - 856 (2007/10/03)

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.

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