343772-39-4Relevant academic research and scientific papers
Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents
Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai
, p. 6961 - 6966 (2021/09/11)
An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.
Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists
Lange, Jos H.M.,Attali, Amos,Van Der Neut, Martina A.W.,Wals, Henri C.,Mulder, Arie,Zilaout, Hicham,Duursma, Ate,Van Aken, Hans H.M.,Van Vliet, Bernard J.
scheme or table, p. 4992 - 4998 (2010/10/05)
The synthesis and SAR of 3-alkyl-4-aryl-4,5-dihydropyrazole-1-carboxamides 1-23 and 1-alkyl-5-aryl-4,5-dihydropyrazole-3-carboxamides 24-27 as two novel cannabinoid CB1 receptor agonist classes were described. The target compounds elicited high
4,5-Dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
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Page/Page column 13; 38, (2010/11/27)
This invention is directed to 4,5-dihydro-(1H)-pyrazole(pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions containing these compounds, to methods for the preparation of these compounds, methods for pr
