343783-04-0Relevant articles and documents
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs
Jackson, Emily R.,San Jose, Géraldine,Brothers, Robert C.,Edelstein, Emma K.,Sheldon, Zachary,Haymond, Amanda,Johny, Chinchu,Boshoff, Helena I.,Couch, Robin D.,Dowd, Cynthia S.
, p. 649 - 653 (2014)
Inhibition of the nonmevalonate pathway (NMP) of isoprene biosynthesis has been examined as a source of new antibiotics with novel mechanisms of action. Dxr is the best studied of the NMP enzymes and several reports have described potent Dxr inhibitors. M
Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues
Ladame, Sylvain,Bardet, Michel,Périé, Jacques,Willson, Michèle
, p. 773 - 783 (2007/10/03)
Various phosphono-phosphates and diphophonates were synthesized as 1,3-diphosphoglycerate 1,3-diPG) analogues by using a β-ketophosphonate, an α-fluoro,β-ketophosphonate or a β-ketophosphoramidate to mimic the unstable carboxyphosphate part of the natural