343808-08-2Relevant academic research and scientific papers
4,5-Disubstituted primaquine analogs as potential antiprotozoan agents
Burghard,DeWitt Blanton Jr.
, p. 933 - 936 (2007/10/02)
4,5-Dimethylprimaquine and 5-fluoro-4-methylprimaquine were synthesized and evaluated against Plasmodium berghei in the mouse. Significant blood schizonticidal activity was observed. The 5-fluoro-4-methylprimaquine analog also was active as a tissue schizonticidal agent when evaluated against P. cynomolgi in the rhesus monkey, as an antileishmanial agent when evaluated against Leishmania donovani in the hamster, and as a causal prophylactic agent when evaluated against P. berghei yoelii.
