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Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Amino-ethyl)-1H-pyrimidine-2,4-dione is used as a key component in the synthesis of pharmaceuticals, particularly for the development of potential anti-cancer and anti-inflammatory drugs. Its unique structure allows for the creation of novel therapeutic agents that can target specific biological pathways, offering new treatment options for various diseases.
Used in Corrosion Inhibition:
AEPD is also utilized as a potential corrosion inhibitor, providing protection for metals and alloys in various industrial applications. Its ability to form a protective layer on metal surfaces helps to prevent corrosion, extending the lifespan of materials and reducing maintenance costs.
Used in Materials Science:
In the field of materials science, 1-(2-Amino-ethyl)-1H-pyrimidine-2,4-dione is investigated for its potential in the development of new polymers and functionalized materials. Its unique chemical properties make it a promising candidate for creating advanced materials with specific characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.
Used in Synthesis of Heterocyclic Compounds:
AEPD serves as a valuable precursor for the synthesis of heterocyclic compounds, which are essential in various chemical and pharmaceutical applications. Its versatile structure allows for the creation of a wide range of heterocyclic compounds with diverse properties and potential uses in different industries.

Upstream product

• 2950-82-5 3-(1-uracilyl)propionic acid 
• 221456-26-4 2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Carbon nanotube-nucleobase hybrids: Nanorings from uracil-modified single-walled carbon nanotubes

Single-walled carbon nanotubes (SWCNTs) have been covalently functionalized with uracil nucleobase. The hybrids have been characterized by using complementary spectroscopic and microscopic techniques including solid-state NMR spectroscopy. The uracil-functionalized SWCNTs are able to self-assemble into regular nanorings with a diameter of 50-70 nm, as observed by AFM and TEM. AFM shows that the rings do not have a consistent height and thickness, which indicates that they may be formed by separate bundles of CNTs. The simplest model for the nanoring formation likely involves two bundles of CNTs interacting with each other via uracil-uracil base-pairing at both CNT ends. These nanorings can be envisaged for the development of advanced electronic circuits. Copyright

Design and synthesis of N-nonpolar nucleobase dipeptides: Application of the Ugi reaction for the preparation of dipeptides havingfluoroarylalkyl groups appended to the nitrogen atom

A single-step one-pot synthesis based on the Ugi four-component condensation of previously unknown dipeptides, 2,3,4 and 5, having afluoroaromatic group appended to the nitrogen atom, is described. The series of dipeptides produced here can be viewed as nonpolar nucleobase dipeptides since the difluorotoluene nucleoside 1 is a well known nonpolar analogue of natural thymidine. A mixture of N-protected amino acids 7, fluorophenethylamines 6, isocyanides 8, and acetone or paraformaldehyde are stirred in methanol in the presence of 3 A molecular sieves to furnish the N-fluoroarylethyl-Aib- or -Gly-containing dipeptides 2 or 3, in moderate yields. The dipeptides 2d and 3b, having a cyclohex-1-enamide moiety, are deprotected readily with 3 M HCl in THF to a3ord the free dipeptides in high yields. The N-fluoroarylmethyl-Aib- or -Gly-containingβ-alanyl dipeptides 4 or 5, designed based on the structure of 2′,5′-linked isoDNA, are also synthesized in a similar fashion to the preparation of 2, in moderate to good yields as both protected and free dipeptides.

SYNTHESIS OF (1-URACILYL)ALKYLAMINES AND THEIR TRANSFORMATION TO TWO-RING SYSTEMS

N-alkylamines were synthesized.It is shown that intramolecular cyclization to give imidazo- and pyrimidopyrimidine systems occurs primarily in the reaction of 5-bromouracil derivatives with primary and secondary amin