3439-74-5Relevant academic research and scientific papers
Synthesis and anticancer activity of triazole linked macrocycles and heterocycles
Rao, Enugala Kalyan,Srinivas, Avula
, p. 404 - 413 (2021/06/25)
Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar
COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION
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Page/Page column 77-78, (2012/02/01)
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
Cyclization of 2-(2-bromoethoxy)-acetophenones and 5-(ω-haloalkoxy)- 1,5-dihydro-2H-pyrrol-2-ones - Formation of five- to eight-membered oxygen-containing heterocycles via intramolecular alkylation
Nikitin, Kirill V.,Andryukhova, Nonna P.
, p. 571 - 578 (2007/10/03)
Under basic conditions (lithium diisopropylamide or sodium hydride in THF) 2-(2-bromoethoxy)-acetophenones were transformed to 3,4-dihydro[1]benzoxepin- 5(2H)-ones (homochromanones) in high yields. The preparation of novel tetrahydropyrano[2,3-b]pyrrol-6(
Use of Polyoxetane Resin-Supported Quaternary Onium Salts as a Polymeric Phase-Transfer Catalyst for Preparing Ethers from Hydroxy Compounds and Alkyl Halides
Motoi, Masatoshi,Shimamura, Katsuhiko,Shimamura, Chikako,Muramoto, Satoru,Kanoh, Shigeyoshi,Suda, Hiroshi
, p. 2553 - 2561 (2007/10/02)
As a polymer support for preparing polymeric phase-transfer catalysts (PTC), soft, moderately polar polyoxetane resins were employed which were synthesized by a cationic ring-opening copolymerization of oxetanes Br(CH2)nOCH2-X with bisoxetanes X-CH2O(CH2)nOCH2-X, where X=3-methyl-3-oxetanyl and n=4 or 6.In a few cases of those polymerizations, 3-(2-oxadecyl)-3-methyloxetane was used as a comonomer with a lipophilic pendant.The terminal bromine of the pendant groups of such polyoxetane resins was quaternized with tributylamine or tributylphosphine in DMF in order to examine the phase-transfer catalyzing ability of the resultant quaternary onium bromides in the etherification reaction between alkyl halides and alcohols or phenols.These reactions gave the desired products in fairly good yields within reaction periods of 1-3 h, indicating that the catalytic activities of those PTCs are comparable to that of tetrabutylammonium bromide.A fairly high catalytic activity of the polymeric PTC was observed at each of ten stages in a process using the polymeric PTC repeatedly for the etherification reaction of 3-hydroxymethyl-3-methyloxethane with 1,4-dibromobutane.
