34397-00-7

Usage

Uses

Used in Organic Synthesis:
Nsc79667 is used as a synthetic compound for various chemical reactions and processes in the field of organic synthesis. Its unique structure allows it to be a valuable building block or intermediate in the creation of more complex molecules and compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Nsc79667 is used as a precursor or intermediate in the development of new drugs. Its chemical properties make it a promising candidate for the synthesis of therapeutic agents, potentially leading to the discovery of novel medications with improved efficacy and safety profiles.
Used in Research and Development:
Nsc79667 is also utilized in research and development settings, where it can be employed to study the properties and behavior of various chemical reactions. This can contribute to a better understanding of the underlying mechanisms and help in the design of more efficient and targeted synthetic pathways.

InChI:InChI=1/C8H8N4O3/c13-5(14)1-2-12-4-11-6-7(12)9-3-10-8(6)15/h3-4H,1-2H2,(H,13,14)(H,9,10,15)

Upstream product

• 95789-89-2 ethyl 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propanoate 
• 7083-40-1 3-(6-aminopurine-9-yl)-propionic acid ethyl ester 
• 66224-66-6 adenine 

Downstream Products

• 138117-79-0 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic acid,ethyl ester 

Relevant academic research and scientific papers

A new method for synthesis and angiogenic evaluation of leteprinim potassium and its novel analogs

We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which is one of the candidate substances for treating Alzheimer's disease, and subsequently synthesized 4 types of corresponding novel derivatives 2-5 that have hypoxanthine or 2-chloro-6-aminopurine as the nucleobase. We then determined the angiogenic activity of these compounds by using human umbilical vein endothelial cells. Compounds 1-4 showed no angiogenic potencies judging from statistical analysis, student's t-test.

Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue

The present invention comprises a method of stimulating regeneration or survival of a mammalian motor neuron or of a mammalian sensory neuron comprising administering to a mammal an effective amount of a compound that is a 9-substituted hypoxanthine derivative linked through a linker to a p-aminobenzoic acid moiety or of a salt or prodrug ester of such a compound. Preferably, the compound is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide. The invention also includes pharmaceutical compositions formulated for stimulation of regeneration of a mammalian motor neuron comprising the 9-substituted hypoxanthine derivative and a pharmaceutically acceptable carrier.

9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use

Novel bi-functional pharmaceutical compounds, particularly novel 9-substituted hypoxanthines of the general formula: STR1 where R is a neurologically active moiety, are described as pharmaceutical agents for treating neuroimmunologic disorders in mammals. Novel methods for the utilization of these compounds are also disclosed. These compounds exhibit uniquely dose-dependent, synergistic biological properties and are particularly useful for treating interrelated physiological systems.