3440-53-7Relevant academic research and scientific papers
Studies on quinazolines. Part I. Annelation to the quinazoline ring utilizing amino acid esters
Wasfy, Ashraf A. F.
, p. 1349 - 1358 (2007/10/03)
The reaction of quinazoline-4(3H)-thiones 2a-d with amino acid ester hydrochlorides in boiling solvents, under the basic catalysis, afforded the corresponding substitution products (3-6)a-e in low yield. The reaction could be improved by carrying it without a solvent yielding imidazo[1,2-c]- and pyrimido[1,2-c]quinazolines (7-10)a-e. The antibacterial and antifungal activities of the prepared compounds were tested.
