34403-27-5Relevant academic research and scientific papers
Iridium-catalyzed highly enantioselective hydrogenation of the C=C bond of α, β-unsaturated ketones
Lu, Wei-Jing,Chen, Yun-Wei,Hou, Xue-Long
supporting information; experimental part, p. 10133 - 10136 (2009/05/30)
(Chemical Equation Presented) A fine selection: The installation of chiral centers at the α position of ketones is achieved with excellent enantioselectivity by means of iridium-catalyzed asymmetric hydrogenation of α,β-unsaturated ketones under mild conditions. The catalyst incorporates a phosphinooxazoline (PHOX)-based ligand, which exhibits high levels of asymmetric induction (see scheme; BArF-= tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; cod=cyclooctadiene).
