34407-66-4

Upstream product

• 3249-94-3 5′-O-trityl-2,2′-anhydro-β-D-uridine 
• 6554-10-5 5'-O-trityluridine 
• 58-96-8 uridine 
• 76-83-5 trityl chloride 

Downstream Products

• 1426142-26-8 4-amino-1-{(5aR,6R,8R,8aS)-5a,6,8,8a-tetrahydro-6-[(triphenylmethoxy)methyl]-4H-furo[3,4-b][1,2,3]-triazolo[1,5-d][1,4]oxazin-8-yl}pyrimidin-2(1H)-one 
• 1426142-20-2 1-{(5aR,6R,8R,8aS)-5a,6,8,8a-tetrahydro-6-[(triphenylmethoxy)methyl]-4H-furo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazin-8-yl}pyrimidine-2,4(1H,3H)-dione 
• 204688-13-1 1-((2R,3R,4S,5R)-3-Amino-4-hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis and Anti-HIV activity of triazolo-fused 2′,3′-cyclic nucleoside analogs prepared by an intramolecular huisgen 1,3-dipolar cycloaddition

Triazolo-fused 2′,3′-cyclic nucleoside analogs were synthesized by an intramolecular 1,3-dipolar cycloaddition of nucleoside-derived azido alkynes in a regio- and stereospecific manner. The uracil base in these target compounds was successfully transformed to the corresponding cytosine. The synthesized compounds were examined in a MAGI assay for their anti-HIV activities, and in a H9 T lymphocytes assay for their cell toxicities. Copyright

Uracil- and thymine-substituted thymidine and uridine derivatives

The four possible 3'-uracil-1-yl and 3'-thymin-1-yl derivatives of 3'- deoxythymidine and the four analogous derivatives of 2'-deoxyuridine have been synthesised from thymidine and uridine, respectively. Advantages of the 2-(methoxycarbonyl)vinyl group to prevent the formation of anhydronucleosides and SnCl2/PhSH/Et3N in relation to H2/Pd for the reduction of most azido groups are disclosed.