344336-58-9

Upstream product

• 84454-75-1 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester 
• 591-51-5 phenyllithium 
• 1474-30-2 ethyl 3-oxo-2-(triphenylphosphoranylidene)-4-hexenoate 

Downstream Products

• 83269-67-4 ethyl 2-butyl-4-ethyl-3-oxo-5-phenylhexanoate 
• 83269-70-9 3-ethyl-2-phenylnonan-4-one 

Relevant academic research and scientific papers

Versatile Route to Substituted Ketones through Charge-Directed Conjugate Addition Reactions

Charge-directed conjugate addition reactions have been applied to the preparation of highly substituted ketones.Acylphosphoranes resulting from conjugate addition-alkylation reactions are reduced by Al-Hg to β-keto esters, which, upon alkylation and hydrolysis, give ketones in high yields.An application of this methodology to the synthesis of 9, the defense substance of L. longipes, is described.