344340-40-5

Usage

Chemical classification

Ketone

Purine base

Commonly found in nucleic acids such as DNA and RNA

Chlorine substitution

On the purine ring

Phenyl group

Attached to the ketone functional group

Unique structure

Combination of purine base, chlorine substitution, and phenyl group

Potential applications

Drug discovery and development

Biological activities

Yet to be explored

Further research needed

To fully understand its capabilities and potential uses

Upstream product

• 70-11-1 α-bromoacetophenone 
• 87-42-3 6-chloropurine 
• 532-27-4 1-chloroacetophenone 
• 87-42-3 6-chloro-7H-purine 

Downstream Products

• 1148034-25-6 2-(6-methoxy-9H-purin-9-yl)-1-phenylethanone 
• 79892-45-8 2-(6-amino-9H-purin-9-yl)-1-phenylethanone 

Relevant academic research and scientific papers

Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors

In this study we report on the design, synthesis and biological characterization of novel N9 or N7 arylethanone-substituted 6-aminopurines and 6-methoxypurines, respectively, as EGF-R and VEGF-R inhibitors. The compounds were initial

Heterocyclic Ambident Nucleophiles. III* The Alkylation of Sodium Adenide

The alkylation of sodium adenide in HCONMe2 (30 deg) with various alkylating agents was analysed by 1H n.m.r. spectroscopy.Widely varying N3:N7:N9 alkylation patterns were observed, depending on the alkylating agent.These patterns are interpreted in terms of the electrostatic, thermodynamic and steric factors involved in the different SN2 transition states appropriate to each alkylating agent.Hydrogen bonding association between the 6-amino group and certain carbonyl containing alkylating agents is proposed to explain the enhancedN7-alkylation in some cases.Support for this latter proposal was obtain from a comparison of the adenine alkylation results with the corresponding alkylation patterns of 6-pivaloylamino- and 6-chloro-purine.