34435-05-7 Usage
Description
Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of PLC, appropriately named sphingomyelinase. C24 Ceramide (d18:1/24:0) is one of the most abundant naturally occurring ceramides. Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing cell-permeable ceramide analogs. A few of the processes regulated by ceramides include apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 34435-05-7 differently. You can refer to the following data:
1. Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase
2. Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase.
Check Digit Verification of cas no
The CAS Registry Mumber 34435-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,4,3 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 34435-05:
(7*3)+(6*4)+(5*4)+(4*3)+(3*5)+(2*0)+(1*5)=97
97 % 10 = 7
So 34435-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+
34435-05-7Relevant articles and documents
Total synthesis of sulfated glycosphingolipid SM1a, a kind of human epithelial carcinoma antigen
Zhang, Pengtao,Wang, Kun,Zhang, Jun,Li, Chunxia,Guan, Huashi
, p. 570 - 583 (2015/01/30)
A highly efficient and practical total synthesis of the sulfated ganglioside SM1a, a kind of human epithelial carcinoma antigen identified in mammalian kidney, has been accomplished for the first time. The characteristic sequence of SM1a, β-D-Galp-(1→3)-β
A HIGHLY STEREOSELECTIVE SYNTHESIS OF 2(S),3(R),4E- AND 2(S),3(R),4Z-N-TETRACOSANOYLSPHINGENINE FROM D-GLUCOSE
Koike, Katsuya,Numata, Masaaki,Sugimoto, Mamoru,Nakahara, Yoshiaki,Ogawa, Tomoya
, p. 113 - 124 (2007/10/02)
The synthesis of 4-E- and 4-Z-D-erythro-ceramide was achieved in 10 steps in ca. 20-30percent overall yield, starting from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose.E- and Z-5-Deoxy-1,2-O-isopropylidene-5-C-tetradecylidene-α-D-xylofuranose were used a
