344359-38-2Relevant articles and documents
7-alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines - Potent inhibitors of the tyrosine kinase c-Src
Widler, Leo,Green, Jonathan,Missbach, Martin,Susa, Mira,Altmann, Eva
, p. 849 - 852 (2007/10/03)
7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl).