344359-52-0

Upstream product

• 2491-37-4 2-bromo-1-(3-hydroxyphenyl)ethanone 

Downstream Products

• 90005-54-2 2-amino-1-(3-hydroxyphenyl)ethyl ketone 
• 14665-75-9 2-amino-1-(3-hydroxy-phenyl)-ethanone; hydrochloride 
• 1420388-33-5 (3-hydroxyphenyl)(5-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone 
• 1420388-33-5 (3-hydroxyphenyl)(4-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone 
• 344427-72-1 N-[3-cyano-4-(3-hydroxy-phenyl)-1H-pyrrol-2-yl]-formamidine 
• 344359-60-0 3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol 
• 344359-56-4 2-amino-4-(3-hydroxy-phenyl)-1H-pyrrole-3-carbonitrile 
• 14665-78-2 N-[2-oxo-2-(3-hydroxyphenyl)ethyl]acetamide 

Relevant academic research and scientific papers

Synthesis and cytotoxic activities of 2-substituted (25R)-spirostan-1,4,6-triene-3-ones via ring-opening/elimination and 'click' strategy

Abstract To develop more effective antitumor steroidal drugs, we synthesized a library including twenty-two novel cytotoxic 2-alkyloxyl substituted (25R)-spirostan-1,4,6-triene-3-ones and corresponding 1,2,3-triazoles through an abnormal monoepoxide ring-opening/elimination and 'click' reactions. After the cytotoxic evaluations against HepG2, Caski and HeLa cell lines, three steroidal triazoles 5b, 5f and 5m in this library were found to possess potent anti-proliferative effects against Caski cells with the half-inhibitory concentrations (IC50) of 9.4-11.8 μM. The high-efficient and straightforward process was attractive feature for facile preparation of anti-tumor steroidal triazoles.

COMPOUNDS USEFUL AS MODULATORS OF TRPM8

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

7-alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines - Potent inhibitors of the tyrosine kinase c-Src

7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl).