344564-01-8

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 93578-42-8 2,3-Bis-(3-methoxy-benzyl)-succinic acid diethyl ester 
• 93578-38-2 2,3-Bis-(3-methoxy-benzyl)-succinic acid monoethyl ester 
• 93578-33-7 2-[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-3-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-succinic acid 4-ethyl ester 
• 86653-15-8 4-(3-methoxybenzyl)-2(5H)-furanone 
• 86653-16-9 4-<(3-methoxyphenyl)methyl>dihydrofuran-2(3H)-one 
• 874-98-6 1-bromomethyl-3-methoxybenzene 
• 93578-46-2 2,3-Bis-(3-methoxy-benzyl)-butane-1,4-diol 

Downstream Products

• 76543-15-2 (-)-enterolactone 

Relevant academic research and scientific papers

SYNTHESIS OF 13C-LABELLED ESTROGEN ANALOGUES

There is provided a method of producing novel 13C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a13C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is 13C-resorcinol.

Synthesis of 3,4-Bis-dihydro-2(3H)-furanones and 2,3-Bis(m- or p-substituted-benzyl)-butane-1,4-diols.

Stobbe condensation of appropriately substituted aromatic aldehydes with diethyl or dimethyl succinate in the presence of sodium methoxide yields the required starting materials for the synthesis of the title compounds.The diacids (1-4) and half acid-half

DIANIONS OF β-HYDROXY SULFONES: NEW AND GENERAL APPROACH TO SELECTIVE SYNTHESIS OF 2(5H)-FURANONES

Dianions derived from β-hydroxy sulfones are highly reactive toward a variety of electrophiles including alkyl halides, carbonyl compounds, and sodium iodoacetate.A convenient synthetic method for 4-alkyl- and 5-alkyl-2(5H)-furanones has been developed by using these dianions.A new synthetic approach to trans,3,4-bis(3-hydroxybenzyl)dihydro-2(3H)-furanone, the first lignan found in humans, via a facile reduction of 2(5H)-furanone with Mg-methanol is also described.