344566-78-5

Basic information

• Product Name: TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE
• Synonyms: TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE
• CAS NO: 344566-78-5
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.38
• Mol File: 344566-78-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 484.1°C at 760 mmHg
• Flash Point: 246.6°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 1.58E-09mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE(344566-78-5)
• EPA Substance Registry System: TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE(344566-78-5)

Safety Data

• Hazardous Substances Data: 344566-78-5(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE is a chemical compound that belongs to the class of carbamate derivatives. It is a white solid that is mainly used as a pharmaceutical intermediate in the synthesis of various drugs. TERT-BUTYL N-[1-(4-CYANOPHENYL)-4-PIPERIDINYL] CARBAMATE is known for its application in the development of new therapeutic agents and its potential pharmacological activity. It is important to handle and use this chemical with caution, following necessary safety guidelines and regulations to prevent any potential hazards or risks associated with its use.

InChI:InChI=1/C17H23N3O2/c1-17(2,3)22-16(21)19-14-8-10-20(11-9-14)15-6-4-13(12-18)5-7-15/h4-7,14H,8-11H2,1-3H3,(H,19,21)

Upstream product

• 34916-10-4 4-cyanocyclohexanone 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 344566-84-3 C₁₇H₂₅N₃O₃ 
• 1291057-90-3 4-[4-(3-benzo[b]thiophen-3-yl-3-hydroxypropylamino)piperidin-1-yl]benzonitrile 
• 1291057-83-4 4-[4-(3-benzo[b]thiophen-3-yl-3-oxopropylamino)piperidin-1-yl]benzonitrile 
• 281234-90-0 4-(4-Amino-piperidin-1-yl)-benzonitrile 

Relevant articles and documents

Electrochemical Cross-Dehydrogenative Aromatization Protocol for the Synthesis of Aromatic Amines

The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example of an electrochemical cross-dehydrogenative aromatization (ECDA) reaction of saturated cyclohexanones and amines to construct anilines without additional metal catalysts and chemical oxidants. This reaction exhibits a broad scope of cyclohexanones including heterocyclic ketones, affording a variety of aromatic amines with various functionalities, and shows great potential in the synthesis of biologically active compounds.

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

Further investigation of the recently reported piperidine-4-yl- aminopyrimidine class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out. Thus, preparation of a series of N-phenyl piperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Analogs such as 28 and 40 are very potent versus wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis, structure-activity relationship (SAR), clearance data, and crystallographic evidence for the binding motif are discussed.