344567-18-6Relevant articles and documents
Interplay of Inter- and Intramolecular Interactions in Crystal Structures of 1,3,4-Thiadiazole Resorcinol Derivatives
Hoser, Anna A.,Kamiński, Daniel M.,Skrzypek, Alicja,Matwijczuk, Arkadiusz,Niewiadomy, Andrzej,Gago?, Mariusz,Wo?niak, Krzysztof
, p. 3851 - 3862 (2018/06/11)
Five new 1,3,4-thiadiazole derivatives have been synthesized, and their crystal structures have been determined by single crystal X-ray diffraction. The influence of substituents on molecular geometry and the three-dimensional arrangement of molecules has
A new approach to the synthesis of 2-aryl-substituted benzimidazoles, quinazolines, and other related compounds and their antibacterial activity
Los, Renata,Wesolowska-Trojanowska, Marta,Malm, Anna,Karpiaska, Monika M.,Matysiak, Joanna,Niewiadomy, Andrzej,Glaszcz, Urszula
body text, p. 265 - 275 (2012/09/08)
A new synthesis method of benzimidazoles, dihydroquinazolines, and other related compounds containing a 2,4-dihydroxyphenyl moiety was elaborated. Their structures were identified from elemental, infrared, 1H NMR, 13C NMR, and mass spectra analyses. The minimal inhibitory concentration values of the compounds toward eight reference bacterial strains were determined by the two-fold serial microdilution broth method. The compounds exhibited substantial inhibitory effects against the Gram-positive strains tested contrary to Gram-negative ones. The compounds of imidazopyridine, N-methylbenzimidazole, and dihydroquinazoline structures exhibited the largest activity. The magnification of covering a two-nitrogen atom heterocyclic ring fused to a benzene one decreases the biological effect.
Application of sulfinyl bis(2,4-dihydroxythiobenzoyl) in the synthesis of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles
Matysiak, Joanna,Niewiadomy, Andrzej
, p. 1621 - 1630 (2007/10/03)
One-stage synthesis of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles is described. The compounds were prepared by the reaction of the sulfinyl bis(2,4-dihydroxythiobenzoyl) (STB) with 4-substituted 3-thiosemicarbazides. STB was obtained
