344591-91-9

Usage

Uses

Used in Organic Synthesis:
1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID is used as a building block for the synthesis of complex organic molecules, facilitating the formation of carbon-carbon and carbon-heteroatom bonds. Its reactivity with various compounds makes it a valuable component in the creation of new chemical entities.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID is used as a key intermediate in the development of new drugs. Its versatility in forming different types of chemical bonds allows for the exploration of novel therapeutic agents with potential applications in various medical fields.
Used in Agrochemicals:
1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID is also utilized in the agrochemical industry as a building block for the synthesis of new pesticides and other crop protection agents. Its ability to form stable bonds with various compounds contributes to the development of effective and environmentally friendly agrochemicals.
Used in Anti-Inflammatory Applications:
1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID has demonstrated potential as an anti-inflammatory agent in preclinical studies. It is used for its ability to modulate inflammatory pathways and reduce inflammation, offering a promising therapeutic option for various inflammatory conditions.
Used in Anti-Tumor Applications:
In the field of oncology, 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID has shown potential as an anti-tumor agent. It is used for its ability to target and inhibit the growth of cancer cells, providing a novel approach to cancer treatment and potentially improving patient outcomes.

InChI:InChI=1/C5H6BF3N2O2/c1-11-4(6(12)13)2-3(10-11)5(7,8)9/h2,12-13H,1H3

Upstream product

• 154471-65-5 1-methyl-3-trifluoromethylpyrazol 
• 121-43-7 Trimethyl borate 
• 497832-99-2 4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole 

Downstream Products

• 839714-55-5 5-(2-methoxy-5-nitro-phenyl)-1-methyl-3-trifluoromethyl-1H-pyrazole 
• 1138449-66-7 5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione 
• 1138449-68-9 5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione 
• 1210043-71-2 tert-butyl 2-(benzyloxycarbonylamino)-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)thiophene-3-carboxylate 
• 1210043-63-2 C₂₀H₁₈F₃N₃O₄S 
• 1355631-31-0 N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt 
• 1355636-66-6 4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenol 
• 1361379-34-1 (2-chlorophenyl)-N-{2-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl](1,3-thiazol-5-yl)}carboxamide 
• 1361379-76-1 (2-fluorophenyl)-N-{5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl](2-thienyl)}carboxamide 
• 1361379-79-4 (2,6-difluorophenyl)-N-{5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl](2-thienyl)}carboxamide 
• 1361380-61-1 C₁₆H₉F₅N₄O₃S 
• 1366109-54-7 N-(2-fluorophenyl){5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]selenophen-2-yl}carboxamide 
• 1366110-06-6 (2-fluorophenyl)-N-{5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl](1,3-selenazol-2-yl)}carboxamide 
• 1366110-10-2 (2-chlorophenyl)-N-{5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl](1,3-selenazol-2-yl)}carboxamide 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5, and n is 1 or 2; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to

Herbicidal 2-pyrazolyl-6-aryloxypyri(mi)dines

The invention relates to novel compounds of formula I: wherein R1 through R5, A, X and Z have the meaning set forth in the description. Furthermore the invention relates to a process for the preparation of the novel compounds of formula I, to a novel pyrazol-5-ylboronic acid of formula V, which is used in said process wherein R3 through R5 have the meaning set forth in the description and to a herbicidal composition containing such compounds as active ingredients

Herbicidal 2-Pyrazolyl-6-Aryloxy-Pyri(mi)dines

The invention relates to novel compounds of formula I: wherein R1 through R5, A, X and Z have the meaning set forth in the description. Furthermore the invention relates to a process for the preparation of the novel compounds of formula I, to a novel pyrazol-5-ylboronic acid of formula V, which is used in said process wherein R3 through R5 have the meaning set forth in the description and to a herbicidal composition containing such compounds as active ingredients