344591-91-9

Basic information

• Product Name: 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID
• Synonyms: 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID;AKOS BRN-1191;1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-boronic acid;5-Borono-1-methyl-3-(trifluoromethyl)-1H-pyrazole;(1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)boronic acid;3-(trifluoroMethyl)-1-Methyl-1H-pyrazol-5-yl-5-boronic acid;B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid;Boronic acid, B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-
• CAS NO: 344591-91-9
• Molecular Formula: C₅H₆BF₃N₂O₂
• Molecular Weight: 193.9195496
• Product Categories: Organoborons;Pyrazole
• Mol File: 344591-91-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 132-137°C
• Boiling Point: 311.255°C at 760 mmHg
• Flash Point: 142.042°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: 2-8°C
• PKA: 6.97±0.58(Predicted)
• CAS DataBase Reference: 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID(344591-91-9)
• EPA Substance Registry System: 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID(344591-91-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 344591-91-9(Hazardous Substances Data)

Usage

General Description

1-Methyl-3-trifluoromethylpyrazole-5-boronic acid is a chemical compound that belongs to the class of boronic acids. It is a white solid with the molecular formula C7H8BF3N2O2 and a molecular weight of 209.96 g/mol. 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID is commonly used as a building block in organic synthesis and medicinal chemistry. It is known for its ability to react with a variety of different compounds, making it a versatile tool in the development of new pharmaceuticals and agrochemicals. 1-Methyl-3-trifluoromethylpyrazole-5-boronic acid is a valuable reagent for the formation of carbon-carbon and carbon-heteroatom bonds, and it has demonstrated potential as an anti-inflammatory and anti-tumor agent in preclinical studies.

InChI:InChI=1/C5H6BF3N2O2/c1-11-4(6(12)13)2-3(10-11)5(7,8)9/h2,12-13H,1H3

Upstream product

• 497832-99-2 4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole 
• 121-43-7 Trimethyl borate 
• 154471-65-5 1-methyl-3-trifluoromethylpyrazol 

Downstream Products

• 839714-55-5 5-(2-methoxy-5-nitro-phenyl)-1-methyl-3-trifluoromethyl-1H-pyrazole 
• 1138449-66-7 5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione 
• 1138449-68-9 5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione 
• 1429341-05-8 3-(2,6-difluoro-phenyl)-7-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1429341-34-3 3-(2-chlorophenyl)-7-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 1346665-35-7 2-chloro-N-(2-methoxy-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)benzamide 
• 1346665-31-3 4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide 
• 1346665-28-8 C₁₃H₁₀F₄N₂O₂ 
• 1346665-40-4 C₁₁H₉F₃N₄O₂ 
• 1346665-41-5 N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzo[d]oxazole-2-carboxamide 
• 1346665-42-6 N-(3-amino-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)benzo[d]oxazole-2-carboxamide 
• 1279103-40-0 2-(2,6-difluoro-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole 
• 1210043-63-2 C₂₀H₁₈F₃N₃O₄S 
• 1210043-71-2 tert-butyl 2-(benzyloxycarbonylamino)-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)thiophene-3-carboxylate 

Relevant articles and documents

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to

Herbicidal 2-Pyrazolyl-6-Aryloxy-Pyri(mi)dines

The invention relates to novel compounds of formula I: wherein R1 through R5, A, X and Z have the meaning set forth in the description. Furthermore the invention relates to a process for the preparation of the novel compounds of formula I, to a novel pyrazol-5-ylboronic acid of formula V, which is used in said process wherein R3 through R5 have the meaning set forth in the description and to a herbicidal composition containing such compounds as active ingredients