3446-79-5

Usage

Molecular weight

315.76 g/mol

Structure

1H-Indole-3-acetic acid derivative with a (4-chlorophenyl)methyl group at position 1 and a methoxy group at position 5

Biological activity

Potential biological activities, possibly as a pharmaceutical agent or research tool

Involvement in plant growth and development

It is a derivative of the plant hormone indole-3-acetic acid, which is involved in plant growth and development.

Structure-activity relationship

The addition of a 4-chlorophenyl group and a 5-methoxy group to the indole core modifies its biological properties.

Cellular interaction

The compound's structure suggests that it may interact with cellular receptors and signaling pathways.

Further investigation needed

Further investigation is needed to uncover its potential therapeutic applications.

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 55887-55-3 N,O-Bis(trimethylsilyl)-5-methoxyindolyl-3-essigsaeureester 
• 3471-31-6 5-methoxy-1H-indole-3-acetic acid 

Relevant academic research and scientific papers

Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described. Copyright

Gas chromatographic/mass spectrometric determinations of indomethacin serum levels in the course of pharmacokinetic studies in healthy volunteers

For 4 different brands of indometacin preparations the in vitro dissolution data as well as their relative bioavailabilities were determined. The in vitro tests were performed by the rotating basket method; the quantitative determinations of the serum-levels were determined by a gas chromatographic/mass spectrometric assay employing registration of the characteristic selected ion current profiles of the compound. Furthermore a special method for synthesis of the needed internal standard was also developed. The in-vivo-studies (with 15 volunteers in a 4 fold cross-over) showed - in contrast to the worse in-vitro-dissolution of one preparation - bioequivalency of all four preparations. Our results clearly show that statements on in-vitro/in-vivo correlations have to be cautious.