344776-71-2Relevant articles and documents
Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal
Gong,Kato,Kimoto
, p. 25 - 28 (2001)
Thermal substitution of 4-hydroxypyridine 1 with trifluoroacetaldehyde ethyl hemiacetal (TFAE) leads to a moderate yield of 3-(1-hydroxy-2,2,2-trifluoroethyl)-4-hydroxypyridine 7 in the presence of a catalytic amount of anhydrous potassium carbonate. Under similar conditions, several α-trifluoromethyl hydroxypyridinemethanols 8-15 are easily prepared from 2- or 3-hydroxypyridines 2-6.