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6-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)-3-pyridinol is a chemical compound with the molecular formula C9H10F3NO2. It is a derivative of 3-pyridinol, featuring a methyl group at the 6th position and a trifluoro-1-hydroxyethyl group at the 2nd position. 6-METHYL-2-(2,2,2-TRIFLUORO-1-HYDROXYETHYL)-3-PYRIDINOL is known for its potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of various drugs. Its unique structure, which includes a trifluoromethyl group, can enhance the lipophilicity and metabolic stability of the resulting compounds, making it a valuable intermediate in medicinal chemistry. The compound's properties, such as its reactivity and solubility, are influenced by the presence of the fluorine atoms, which can also affect its biological activity.

344776-71-2

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344776-71-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 344776-71-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,7,7 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 344776-71:
(8*3)+(7*4)+(6*4)+(5*7)+(4*7)+(3*6)+(2*7)+(1*1)=172
172 % 10 = 2
So 344776-71-2 is a valid CAS Registry Number.

344776-71-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-ol

1.2 Other means of identification

Product number -
Other names 2-(1-hydroxy-2,2,2-trifluoroethyl)-3-hydroxy-6-methylpyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:344776-71-2 SDS

344776-71-2Downstream Products

344776-71-2Relevant academic research and scientific papers

Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal

Gong,Kato,Kimoto

, p. 25 - 28 (2001)

Thermal substitution of 4-hydroxypyridine 1 with trifluoroacetaldehyde ethyl hemiacetal (TFAE) leads to a moderate yield of 3-(1-hydroxy-2,2,2-trifluoroethyl)-4-hydroxypyridine 7 in the presence of a catalytic amount of anhydrous potassium carbonate. Under similar conditions, several α-trifluoromethyl hydroxypyridinemethanols 8-15 are easily prepared from 2- or 3-hydroxypyridines 2-6.

SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS

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Page/Page column 74-75, (2010/11/24)

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

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