344796-29-8Relevant academic research and scientific papers
A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactions
Suen, Linda M.,Steigerwald, Michael L.,Leighton, James L.
, p. 2413 - 2417 (2013/07/11)
A new diaminophenol ligand for crotylsilylation reactions with cis- and trans-crotyltrichlorosilane has been developed. The conformational constraints that result from the tethering of the phenol to one of the amino groups attenuate the stereoelectronic effects that reduce activity in the corresponding untethered diaminosilanes, and the resulting crotylsilane reagents are as active as our previously reported EZ-CrotylMix reagents, but without requiring the use of the Sc(OTf)3 catalyst. In turn, this has allowed the development of an experimentally straightforward, sustainable, efficient, and scalable one-pot procedure which may be carried out in ≤8 hours, and in which the diaminophenol activator ligand may be easily recovered in ≥90% yield by recrystallization.
An improved procedure for the separation of (+) or (-)-isopinocampheol, the major side product of the oxidation workup procedure of Brown's asymmetric crotylborations
Hua, Zhengmao,Jin, Zhendong
, p. 7695 - 7697 (2008/03/30)
Separation of (+) or (-)-isopinocampheol, the major side product of the oxidation workup procedure of Brown's asymmetric reactions such as crotylborations from the desired product is quite tedious and often requires repeated column chromatography. It is discovered that a sublimation process can be used to easily separate this major side product.
Synthetic studies of antitumor natural products superstolides A and B. Construction of C20-C26 fragment of superstolide A.
Yu,Zhang,Jin
, p. 1447 - 1450 (2007/10/03)
[structure: see text] The C20-C26 portion of the antitumor macrolide superstolide A was synthesized by employing Brown's asymmetric crotylboronate methodology.
