344799-91-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents
Marchand, Pascal,Antoine, Maud,Baut, Guillaume Le,Czech, Michael,Baasner, Silke,Guenther, Eckhard
experimental part, p. 6715 - 6727 (2009/12/06)
The synthesis and study of the structure-activity relationships of cytotoxic compounds based on N-pyridinyl or N-aryl-2-(1-benzylindol-3-yl)glyoxamide skeleton, represented by the lead structures D-24241 and D-24851, are described. The presence of N-(pyridin-4-yl) moiety was crucial for activity and 2-[1-(4-chloro-3-nitrobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)aceta mide (55), the most potent derivative, showed IC50 = 39 nM, 51 nM and 11 nM against HeLa/KB (human cervix carcinoma), L1210 (murine leukemia) and SKOV3 (human ovarian carcinoma) cell lines proliferation assay, respectively, as active as the lead compounds.
Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
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, (2008/06/13)
The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possi
