3448-12-2

Basic information

• Product Name: (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE
• Synonyms: (1,1-DIOXO-TETRAHYDRO-1LAMBDA6-THIOPHEN-3-YL)-HYDRAZINE;(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE;1-(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE;AKOS BBS-00004840;3-HYDRAZINOTETRAHYDROTHIOPHENE-1,1-DIOXIDE;IFLAB-BB F1294-0038;(tetrahydro-3-thienyl)hydrazine S,S-dioxide;Einecs 222-368-3
• CAS NO: 3448-12-2
• Molecular Formula: C₄H₁₀N₂O₂S
• Molecular Weight: 150.2
• EINECS: 222-368-3
• Mol File: 3448-12-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 427.6 °C at 760 mmHg
• Flash Point: 212.4 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 1.62E-07mmHg at 25°C
• PKA: 6.05±0.20(Predicted)
• CAS DataBase Reference: (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE(3448-12-2)
• EPA Substance Registry System: (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE(3448-12-2)

Safety Data

• Hazardous Substances Data: 3448-12-2(Hazardous Substances Data)

Usage

General Description

(1,1-Dioxidotetrahydrothien-3-yl)hydrazine is a chemical compound with the molecular formula C4H10N2OS. It is a hydrazine derivative with a thienyl ring and a dioxido substituent. (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)HYDRAZINE may have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. It is important to handle and use this chemical with caution, as it may have hazardous properties and should be stored and managed according to proper safety guidelines and regulations.

InChI:InChI=1/C4H12N2O2S/c5-6-4-1-2-9(7,8)3-4/h4H,1-3,6H2,5H3/q+2/t4-/m1/s1

Downstream Products

• 27280-97-3 2-(1,1-dioxo-tetrahydro-1λ⁶-[3]thienyl)-5-methyl-2H-pyrazol-3-ylamine 
• 1421923-83-2 C₁₇H₁₅F₆N₅O₃S 
• 443781-87-1 C₁₁H₁₄N₂O₂S 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.