344874-83-5Relevant academic research and scientific papers
Synthesis and Mass Spectral Studies of Some 2-(3'-Methylpyrazol-5'-yl)benzothiazoles
Singh, S. P.,Prakash, Indra,Tomer, R. K.,Trakash, O. M.,Sawhney, S. N.
, p. 43 - 47 (2007/10/02)
2-Acetoacetylbenzothiazole (III) has been prepared either by the reaction between ethyl benzothiazole-2-carboxylate (I) and acetone or by the reaction of 2-benzothiazolyl methyl ketone (II) with ethyl acetate.Condensation of III with hydrazines affords the title componds (V) through the intermediacy of hydrazone (IV).The mass spectra of V reveal that the molecular ion undergoes fragmentation via three principal modes: (a) fission of benzothiazole ring, (b) fission of pyrazole ring resulting either in the loss of N2R radical or in the formation of aryldiazonium cation,and (c) fission of pyrazole ring with concomitant loss of CH3CN.Compound IVc (R = 0C6H5) exhibits mild antiinflammatory activity.
