34492-32-5

Usage

InChI:InChI=1/C4H8Cl4NPS/c5-1-3-9(4-2-6)10(7,8)11/h1-4H2

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 

Downstream Products

• 91725-65-4 2--1,3,2-oxathiaphosphorinan-sulfid-(2) 
• 34492-36-9 C₃₆H₄₄Cl₂N₃O₂PS 
• 34492-35-8 C₃₄H₄₀Cl₂N₃O₂PS 
• 34492-38-1 C₁₆H₃₂Cl₂N₃PS 

Relevant academic research and scientific papers

Preparation, structure, and reactivity of a new heterocyclic system-1-thio-2,8-diphenyl-2,5,8-triaza-1 λ5-phosphabicyclo[3.3.0]octane

A new heterocyclic system, 1-thio-2,8-diphenyl-2,5,8-triaza-1 λ5-phosphabicyclo[3.3.0]octane, has been prepared, and its structure was confirmed by single-crystal X-ray diffraction. Preliminary reactivity studies demonstrated a complex mechanis

Amido phosphate bis-curcumin ester compound, preparation method and application

The invention discloses an amido phosphate bis-curcumin ester compound, a preparation method and application, and belongs to the field of medicinal chemistry. The compound has the structural formula as follows (referring to the description). The R1 and R2 in the formula (I) can form a saturated nitrogen heterocyclic ring structure as follows through cyclization (referring to the description). The preparation method of the compound comprises the following steps: firstly, preparing amino phosphoryl chloride or thio amino phosphoryl chloride; then reacting with curcumin to obtain the compound. The amido phosphate bis-curcumin ester compound provided by the invention has relatively good antineoplastic activity, the toxicity of the compound is smaller than that of cisplatin, and the compound can be used for preparing medicine for resisting lung cancer, stomach cancer, leukemia, breast cancer and inflammation.

In search of new organophosphorus pesticides and insecticides. Part III: Synthesis and anticholinesterase studies of 3-(subs)-quinoxy/pyridinoxy/cyclica mino-2,3-dihydro-2-(4-chlorophenyl)-1H-naphth [1,2-E][1,3,2] oxazaphosphorine 3-sulfides

In situ treatment of (cyclic) amino derivatives with the product obtained from the cyclocondensation of 1-p-chloroanilinomethyl naphthol-2 and thiophosphoryl chloride in dry benzene-THF afforded the titled oxazaphosphorine sulfides in good yield. Subsequently, the reaction of pyridinoxy/quinoxythiophosphorodi chloridates and 1-p-chloro anilino methyl naphthol-2 in dry benzene-THF mixture gave the corresponding pyridinoxy/quinoxy oxaza phosphorine 3-sulfides in quantitative yield. All the condensations proceeded smoothly by employing triethylamine to scavenge the liberated hydrogen chloride gas. Anticholinestease studies of these compounds indicated very high degree of inhibition several times higher than the reference standard-methyl parathion.

New Dihydrazido and Oxyamido Derivatives of Phosphoric and Thiophosphoric Acid with Bis(2-chloroethyl)amido Substituents

(Cl-CH2CH2)2N-P(=X)Cl2, X = O, reacts with 1,2-dimethylhydrazine in the presence of triethylamine to give the dihydrazide.Hexahydropyridazine as "cyclic hydrazine" leads to a tetracyclic side product formed by HCl elimination from the reactive 2-chloroethyl groups and active β-NH protons of the hexahydropyridazinyl substituents.The corresponding thio-compound, X = S, yields the monosubstitution product (Cl-CH2CH2)2N-P(=S)(N(CH3)-N(CH3)H)Cl.O-Benzylhydroxyamine hydrochloride substitutes both Cl-atoms at P to form (Cl-CH2CH2)2N-P(=S)(NH-O-CH2-C6H5)2.The corresponding phenylesters C6H5O-P(=X)(NH-O-CH2-C6H5)2, X = O, S, are prepared in a similar reaction. - Keywords: N-Lost Derivatives, O-Benzyloxyamido Derivatives