344954-82-1

Basic information

• Product Name: (6R)-(tert-butyl-dimethyl-silanyloxy)-(5R)-hydroxy-2,(10S)-dimethyl-1-(2-methyl-thiazol-4-yl)-trideca-(1E,11Z)-dien-3-one
• Synonyms: (6R)-(tert-butyl-dimethyl-silanyloxy)-(5R)-hydroxy-2,(10S)-dimethyl-1-(2-methyl-thiazol-4-yl)-trideca-(1E,11Z)-dien-3-one
• CAS NO: 344954-82-1
• Molecular Weight: 465.773
• Mol File: 344954-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R)-(tert-butyl-dimethyl-silanyloxy)-(5R)-hydroxy-2,(10S)-dimethyl-1-(2-methyl-thiazol-4-yl)-trideca-(1E,11Z)-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (6R)-(tert-butyl-dimethyl-silanyloxy)-(5R)-hydroxy-2,(10S)-dimethyl-1-(2-methyl-thiazol-4-yl)-trideca-(1E,11Z)-dien-3-one(344954-82-1)
• EPA Substance Registry System: (6R)-(tert-butyl-dimethyl-silanyloxy)-(5R)-hydroxy-2,(10S)-dimethyl-1-(2-methyl-thiazol-4-yl)-trideca-(1E,11Z)-dien-3-one(344954-82-1)

Safety Data

• Hazardous Substances Data: 344954-82-1(Hazardous Substances Data)

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Downstream Products

• 152044-53-6 epithilone A 

Relevant articles and documents

Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies

The expedient and fully stereocontrolled synthesis of epothilones A and B are described. The routes described make extensive study of nitrile oxide cycloadditions as surrogates for aldol addition reactions and have led to the realization of a highly convergent synthesis based on the Kanemasa hydroxyl-directed nitrile oxide cycloaddition. As well, our synthetic efforts have led to the development of new reaction methodologies and served as the proving ground for several modern methods for asymmetric carbon-carbon bond formation.