34520-59-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
TFPD is utilized as a key building block in the synthesis of various pharmaceutical and agrochemical compounds, contributing to the development of new drugs and pesticides.
Used in Medical Applications:
1-(2-Trifluoromethyl-phenyl)-pyrrole-2,5-dione is used as a potential diuretic agent for promoting the increase of urine output, aiding in the management of conditions related to fluid retention.
1-(2-Trifluoromethyl-phenyl)-pyrrole-2,5-dione is also used as a potential antihypertensive agent for the treatment of high blood pressure, helping to lower and regulate blood pressure levels.
Used in Research and Development:
TFPD is employed in preclinical studies for exploring its therapeutic applications in various diseases, making it a valuable subject for further research aimed at identifying new treatment options.

InChI:InChI=1/C11H6F3NO2/c12-11(13,14)7-3-1-2-4-8(7)15-9(16)5-6-10(15)17/h1-6H

Upstream product

• 85843-25-0 (Z)-3-(2-Trifluoromethyl-phenylcarbamoyl)-acrylic acid 
• 108-31-6 maleic anhydride 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 1025705-35-4 2-oxo-N-(2-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimida-zole-4-carboxamide 
• 1246040-95-8 7-oxo-N-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-5-carboxamide 
• 1147199-80-1 C₁₃H₁₀F₃N₅O₂ 
• 1170055-05-6 5-oxo-3-phenyl-N-[2-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-7-carboxamide 
• 1305287-22-2 3-methyl-6-oxo-1-phenyl-N-[2-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridine-4-carboxamide 

Relevant academic research and scientific papers

Dual organic dyes as a pseudo-redox mediation system to promotion of tandem oxidation /[3+2] cycloaddition reactions under visible light

An atom- and step-economy protocol has been developed to synthesize some new biologically active pyrrolo[2,1-a]isoquinoline alkaloids via redox mediation system under visible light irradiation. A vast variety of double and triple bonds, as dipolarophiles, treated with in situ generated azomethine ylides to prepare corresponding products in good to excellent yields. This metal-free method effectively promoted oxidation/[3 + 2] cycloaddition/oxidative/aromatization domino reaction without further oxidant using dual organic dyes as pseudo-redox mediation system. Besides, for most of the products, product precipitate was readily separated from reaction media. To the best of our knowledge, this is the first report of dual dyes as a pseudo-redox mediation system.

Photoorganocatalysed and visible light photoredox catalysed trifluoromethylation of olefins and (hetero)aromatics in batch and continuous flow

Trifluoromethylation of olefins and (hetero)aromatics with sodium triflinate as CF3 source and readily accessible benzophenone derivatives as photosensitisers has been developed in batch and flow. The use of an iridium-based photocatalyst enables the trifluoromethylation to proceed under visible light irradiation.

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B

Structural optimization and preliminary structure-activity relationship studies of a series of N-substituted maleimide fused-pyrazole analogues with Cdc25B inhibitory activity, starting from a high-throughput screening hit, are illustrated. A simplified 3,5-diacyl pyrazole analogue was obtained as the most potent compound (118, IC50 = 0.12 μM) with a 270-fold increase in potency.

AROMATIC MALEIMIDES AND THEIR USE AS PHOTOINITIATORS

Aromatic maleimides and methods using the same are disclosed. Polymerization of compositions which include the compounds of the invention may be activated by irradiating the composition with radiation.

Evaluation of N-aromatic maleimides as free radical photoinitiators: A photophysical and photopolymerization characterization

Photopolymerizable compositions were prepared using acrylate monomers in combination with various N-aromatic maleimides. N-aromatic maleimides were segregated into two groups: those that could adopt a planar conformation and those that could not adopt a planar conformation. The maleimides were characterized using single-crystal X-ray diffraction spectroscopy, laser flash photolysis spectroscopy, UV-vis absorption spectroscopy, and photodifferential scanning calorimetry. Planar N-aromatic maleimides were found to have a low relative excited-state triplet yield, showing significant shift of the primary maleimide UV absorption band with changes in solvent polarity, and did not initiate free radial polymerization upon direct UV excitation. Twisted N-aromatic maleimides have a higher relative triplet yield, show negligible shift of the primary maleimide UV absorption band, with solvent polarity, and initiate free radical polymerization upon direct excitation. Addition of benzophenone was found to dramatically increase the initiation efficiency of both planar and twisted N-aromatic maleimides to levels approaching that of conventional cleavage photoinitiators.

N-arylmaleimide derivatives

Nine phenyl substituted N-phenylmaleimide monomers for photopolymerization studies have been characterized by x-ray crystallography. Structures for N-(2′-t-butylphenyl)maleimide (1), P21/n, a = 10.197(3) A, b = 11.904(4) A, c = 10.496(5) A, β =