345218-02-2

Upstream product

• 345217-81-4 2-(dimethyl-phenyl-silanyl)-3-phenyl-propionic acid 
• 345217-85-8 2-(dimethyl-phenyl-silanyl)-3-phenyl-propen-1-one 
• 17887-62-6 (dimethylphenylsilyl)acetic acid 
• 345217-96-1 2-(dimethyl-phenyl-silanyl)-3-phenyl-thiopropionic acid S-phenyl ester 

Downstream Products

• 86551-93-1 (2S)-3-phenyl-propane-1,2-diol diacetate 

Relevant academic research and scientific papers

Copper-catalyzed enantioselective hydroboration of unactivated 1, 1-disubstituted alkenes

We report an efficient and highly enantioselective hydroboration of aliphatic 1, 1-disubstituted alkenes with pinacolborane using a phosphine-Cu catalyst. The method allows facile preparation of enantiomerically enriched β-chiral alkyl pinacolboronates from a range of 1, 1-disubstituted alkenes with high enantioselectivity up to 99% ee. Unprecedented enantiodiscrimination between the geminal alkyl substituents was observed with functional group compatibility in the hydroboration. Furthermore, a catalyst loading as low as 1 mol % furnished the desired product without a decrease in yield or selectivity, demonstrating its efficiency in gram scale synthesis.

The highly enantioselective transformation of silylketenes into α-silylthioesters catalysed by cinchona alkaloids

The reaction of silylketenes with thiophenol, mediated by cinchona alkaloid catalysts, proceeds to give α-silylthioester products in good chemical yield and with enantiomeric excess values in the range 79-93%. The absolute configuration of one of the thioester products was determined by X-ray diffraction.