345218-02-2

Basic information

• Product Name: (S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol
• Synonyms: (S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol
• CAS NO: 345218-02-2
• Molecular Weight: 270.447
• Mol File: 345218-02-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol(345218-02-2)
• EPA Substance Registry System: (S)-2-(dimethyl(phenyl)silyl)-3-phenylpropan-1-ol(345218-02-2)

Safety Data

• Hazardous Substances Data: 345218-02-2(Hazardous Substances Data)

Upstream product

• 345217-81-4 2-(dimethyl-phenyl-silanyl)-3-phenyl-propionic acid 
• 17887-62-6 (dimethylphenylsilyl)acetic acid 
• 345217-96-1 2-(dimethyl-phenyl-silanyl)-3-phenyl-thiopropionic acid S-phenyl ester 
• 345217-85-8 2-(dimethyl-phenyl-silanyl)-3-phenyl-propen-1-one 

Downstream Products

• 86551-93-1 (2S)-3-phenyl-propane-1,2-diol diacetate 

Relevant articles and documents

Copper-catalyzed enantioselective hydroboration of unactivated 1, 1-disubstituted alkenes

We report an efficient and highly enantioselective hydroboration of aliphatic 1, 1-disubstituted alkenes with pinacolborane using a phosphine-Cu catalyst. The method allows facile preparation of enantiomerically enriched β-chiral alkyl pinacolboronates from a range of 1, 1-disubstituted alkenes with high enantioselectivity up to 99% ee. Unprecedented enantiodiscrimination between the geminal alkyl substituents was observed with functional group compatibility in the hydroboration. Furthermore, a catalyst loading as low as 1 mol % furnished the desired product without a decrease in yield or selectivity, demonstrating its efficiency in gram scale synthesis.