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2-CHLORO-4-TRIFLUOROMETHOXYBENZENEBORONIC ACID, also known as (2-Chloro-4-trifluoromethoxyphenyl)boronic Acid, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a boronic acid group, which allows it to participate in various chemical reactions, making it a versatile building block in organic synthesis.

345226-20-2

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345226-20-2 Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-4-TRIFLUOROMETHOXYBENZENEBORONIC ACID is used as an intermediate for the preparation of azaand diazabiphenyl analogs of the antitubercular drug (6S)-2-nitro-6-[4-(trifluoromethoxy)benzyl]oxy-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine. This application is significant in the development of new antitubercular drugs to combat drug-resistant tuberculosis.
Used in Organic Synthesis:
2-CHLORO-4-TRIFLUOROMETHOXYBENZENEBORONIC ACID is used as a key component in the synthesis of aryl(alkylamino)nitropyridines. This process involves amination of chlorohydroxynitropyridine with aliphatic amines, followed by chlorination, and then Suzuki-coupling with arylboronic acids. This application highlights its importance in the development of new organic compounds with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 345226-20-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,5,2,2 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 345226-20:
(8*3)+(7*4)+(6*5)+(5*2)+(4*2)+(3*6)+(2*2)+(1*0)=122
122 % 10 = 2
So 345226-20-2 is a valid CAS Registry Number.

345226-20-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-4-trifluoromethoxyphenylboronic acid

1.2 Other means of identification

Product number -
Other names (2-Chloro-4-(trifluoromethoxy)phenyl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:345226-20-2 SDS

345226-20-2Downstream Products

345226-20-2Relevant academic research and scientific papers

Pyrazolyl-Based Carboxamides II

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Paragraph 0399-0400, (2014/07/22)

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS

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Page/Page column 52; 53, (2014/07/23)

The invention relates to pyrazolyl-based carboxamide compounds of formula (I) useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824)

Kmentova, Iveta,Sutherland, Hamish S.,Palmer, Brian D.,Blaser, Adrian,Franzblau, Scott G.,Wan, Baojie,Wang, Yuehong,Ma, Zhenkun,Denny, William A.,Thompson, Andrew M.

experimental part, p. 8421 - 8439 (2011/02/21)

New heterocyclic analogues of the potent biphenyl class derived from antitubercular drug PA-824 were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both phenyl

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