34524-44-2Relevant academic research and scientific papers
A Convenient Protocol for the Synthesis of Fatty Acid Amides
Johansson, Silje J. R.,Johannessen, Tonje,Ellefsen, Christiane F.,Ristun, Mali S.,Antonsen, Simen,Hansen, Trond V.,Stenstrom, Yngve,Nolsoe, Jens M. J.
supporting information, p. 213 - 217 (2019/01/14)
Several classes of biologically occurring fatty acid amides have been reported from mammalian and plant sources. Many amides conjugated with fatty acids of mammalian origin exhibit specific activation of individual receptors. Their potential as pharmacological tools or as lead compounds towards the development of novel therapeutics is of great interest. Hence, access to such amides by a practical, high-yielding and scalable protocol without affecting the geometry or position of sensitive functionalities is needed. A protocol that meets all these requirements involves activation of the corresponding acid with carbonyl diimidazole (CDI) followed by reaction with the desired amine or its hydrochloride. More than fifty compounds have been prepared in generally high yields.
Synthesis and antituberculosis activity of new fatty acid amides
D'Oca, Caroline Da Ros Montes,Coelho, Tatiane,Marinho, Tamara Germani,Hack, Carolina Rosa Lopes,Da Costa Duarte, Rodrigo,Da Silva, Pedro Almeida,D'Oca, Marcelo Gonalves Montes
supporting information; scheme or table, p. 5255 - 5257 (2010/10/03)
This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 μg/mL for resistance strains.
Chiral Aggregation Phenomena. 3. Chiral Discrimination in the Monolayer Packing of N-(α-Methylbenzyl)stearamides on Aqueous Acid Subphases: Thermodynamic Behavior
Arnett, Edward M.,Chao, Jean,Kinzig, Barbara J.,Stewart, Martin V.,Thompson, Orlean,Verbiar, Robert J.
, p. 389 - 400 (2007/10/02)
The study of monolayers at the air-liquid interface offers unusual opportunities to investigate the effects of stereochemical factors in organized systems.As a first step toward developing this field, we have examined some surface properties of N-(α-methy
