345254-80-0Relevant academic research and scientific papers
Palladium-Catalyzed C-P Bond-Forming Reactions of Aryl Nonaflates Accelerated by Iodide
McErlain, Holly,Riley, Leanne M.,Sutherland, Andrew
, p. 17036 - 17049 (2021/11/18)
An iodide-accelerated, palladium-catalyzed C-P bond-forming reaction of aryl nonaflates is described. The protocol was optimized for the synthesis of aryl phosphine oxides and was found to be tolerant of a wide range of aryl nonaflates. The general nature of this transformation was established with coupling to other P(O)H compounds for the synthesis of aryl phosphonates and an aryl phosphinate. The straightforward synthesis of stable, isolable aryl nonaflates, in combination with the rapid C-P bond-forming reaction allows facile preparation of aryl phosphorus target compounds from readily available phenol starting materials. The synthetic utility of this general strategy was demonstrated with the efficient preparation of an organic light-emitting diode (OLED) material and a phosphonophenylalanine mimic.
Visible-light-induced ligand-free RuCl3 catalyzed C-H phosphorylation in water
Gou, Xue-Ya,Zhang, Bo-Sheng,Wang, Xin-Gang,Shi, Wei-Yu,Liu, Hong-Chao,An, Yang,Zhang, Zhe,Liang, Yong-Min
supporting information, p. 4704 - 4707 (2020/05/22)
Visible-light-induced C-H phosphorylation of para-CAr-H and heteroarenes was realized using cost-effective RuCl3 as a catalyst. The reaction conditions are green and environmentally friendly, using water as a solvent at room temperature and without ligands. A broad range of highly functional organophosphorus compounds were obtained via a cross-dehydrogenation-coupling (CDC) reaction. In addition, we also proved that RuCl3 is a photocatalyst via its absorption spectrum and on/off light experiments.
Manganese-Catalyzed and Mediated Synthesis of Arylphosphinates and Related Compounds
Berger, Olivier,Montchamp, Jean-Luc
, p. 9239 - 9256 (2019/08/12)
The free-radical arylation of H-phosphinates and related compounds was examined. A practical catalytic process with the air as the oxidant could not be found. However, an inexpensive and robust methodology was developed, using catalytic Mn(II) as the radi
Manganese-Mediated Intermolecular Arylation of H-Phosphinates and Related Compounds
Berger, Olivier,Montchamp, Jean-Luc
supporting information, p. 12385 - 12388 (2015/02/19)
The intermolecular radical functionalization of arenes with aryl and alkyl H-phosphinate esters, as well as diphenylphosphine oxide and H-phosphonate diesters, is described. The novel catalytic MnII/excess MnIVsystem is a convenient
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: K(ATP) potassium channel openers. Modifications on the western region
Ohnmacht, Cyrus J.,Russell, Keith,Empfield, James R.,Frank, Cathy A.,Gibson, Keith H.,Mayhugh, Daniel R.,McLaren, Frances M.,Shapiro, Howard S.,Brown, Frederick J.,Trainor, Diane A.,Ceccarelli, Christopher,Lin, Margaret M.,Masek, Brian B.,Forst, Janet M.,Harris, Robert J.,Hulsizer, James M.,Lewis, Joseph J.,Silverman, Stuart M.,Smith, Reed W.,Warwick, Paul J.,Kau, Sen T.,Chun, Alexa L.,Grant, Thomas L.,Howe, Burton B.,Li, Jack H.,Trivedi, Shephali,Halterman, Tracy J.,Yochim, Christopher,Dyroff, Martin C.,Kirkland,Neilson, Kathleen L.
, p. 4592 - 4601 (2007/10/03)
A subset of antiandrogen compounds, the N-aryl-3,3,3-trifluoro-2- hydroxy-2-methylpropanamides 1, were found to activate ATP sensitive potassium channels (K(ATP)) and represent a new class of potassium channel openers (PCOs). A structure-activity relation
