345289-40-9

Upstream product

• 72036-30-7 ethyl 3-lithiopropiolate 

Downstream Products

• 345289-41-0 (R)-5-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-ylmethyl]-5H-furan-2-one 
• 168960-59-6 (1R,5S,6R,7S)-6-benzoyloxymethyl-7-hydroxy-2-ocabicyclo<3.2.0>octaan-3-one 
• 345289-43-2 (2R,4aS,4bS,7aR,8aS)-2-Phenyl-hexahydro-furo[3',2':3,4]cyclopenta[1,2-d][1,3]dioxin-6-one 
• 345289-42-1 Thiocarbonic acid O-[(2R,4S,5R)-4-((R)-5-oxo-2,5-dihydro-furan-2-ylmethyl)-2-phenyl-[1,3]dioxan-5-yl] ester O-phenyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of an isoprostane synthon via 8,12-free-radical cyclization

Aiming at a stereocontrolled biomimetic synthesis of isoprostanes a fully stereocontrolled 8,12-free radical cyclization has been achieved via intermediate 10 by annulating an endocyclic radical to a butenolide acceptor double bond. In this way ent-12-epi-PGF2α (ent-2) can be prepared.