345577-77-7Relevant academic research and scientific papers
Cyclic urea derivatives as potent NK1 selective antagonists
Shue, Ho-Jane,Chen, Xiao,Shih, Neng-Yang,Blythin, David J.,Paliwal, Sunil,Lin, Ling,Gu, Danlin,Schwerdt, John H.,Shah, Sapna,Reichard, Gregory A.,Piwinski, John J.,Duffy, Ruth A.,Lachowicz, Jean E.,Coffin, Vicki L.,Liu, Fei,Nomeir, Amin A.,Morgan, Cynthia A.,Varty, Geoffrey B.
, p. 3896 - 3899 (2007/10/03)
A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compoun
Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists
Reichard, Gregory A.,Stengone, Carmine,Paliwal, Sunil,Mergelsberg, Ingrid,Majmundar, Sapna,Wang, Cheng,Tiberi, Robert,McPhail, Andrew T.,Piwinski, John J.,Shih, Neng-Yang
, p. 4249 - 4251 (2007/10/03)
(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
