345577-77-7

Basic information

• Product Name: 4-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one
• CAS NO: 345577-77-7
• Molecular Weight: 418.339
• Mol File: 345577-77-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one(345577-77-7)
• EPA Substance Registry System: 4-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one(345577-77-7)

Safety Data

• Hazardous Substances Data: 345577-77-7(Hazardous Substances Data)

Upstream product

• 582-24-1 1-phenyl-2-hydroxyethanone 
• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 345579-46-6 2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenylethanone 
• 184970-01-2 2-(3,5-bis(trifluoromethyl)benzyloxy)-N-methoxy-N-methylacetamide 
• 345579-47-7 3-(3,5-bis-trifluoromethyl-benzyloxy)-2-phenyl-propane-1,2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 345579-48-8 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-5-phenyl-imidazolidine-2,4-dione 
• 345580-10-1 2-amino-3-(3,5-bis-trifluoromethyl-benzyloxy)-2-phenyl-propionitrile 

Downstream Products

• 345580-16-7 (R)-4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one 

Relevant articles and documents

Cyclic urea derivatives as potent NK1 selective antagonists

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compoun