345632-86-2

Basic information

• Product Name: 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester
• Synonyms: 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester
• CAS NO: 345632-86-2
• Molecular Weight: 471.712
• Mol File: 345632-86-2.mol

Chemical Properties

• CAS DataBase Reference: 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester(345632-86-2)
• EPA Substance Registry System: 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester(345632-86-2)

Safety Data

• Hazardous Substances Data: 345632-86-2(Hazardous Substances Data)

Upstream product

• 345632-84-0 1-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenyl)-propan-2-ol 
• 211935-16-9 3-(2-Nitro-phenyl)-propane-1,2-diol 
• 131423-64-8 benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate 
• 345632-85-1 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol 

Relevant articles and documents

Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s

To investigate the role of the amide hydrogen of benzolactam-V8s (1-3) on protein kinase C (PKC) isozyme binding, new lactone analogues of benzolactam-V8s with hydrophobic side chains at positions 8 and/or 9 (5-8) were synthesized. The PKC binding affinities of 8- and 9-decylbenzolactone-V8 (5,6) were much lower than those of 8- and 9-decylbenzolactam-V8 (2,3), respectively, indicating that the amide hydrogen of benzolactam-V8s plays a critical role in PKC binding. 8-Decylbenzolactam-V8 (2) showed lower binding affinities to all PKC isozymes compared with those of 9-decylbenzolactam-V8 (3). The binding affinities of 8-substituted benzolactones (5,7,8) were also lower than those of 9-decylbenzolactone-V8 (6), but their PKC isozyme selectivity was higher than those of 2, 3 and 6. 8-Decybenzolactone-V8 (5) exhibited the most significant η-C1B selectivity among the four benzolactones (5-8) synthesized in this study.

The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities

To investigate the role of the amide hydrogen of (-)-indolactam-V (1) and benzolactam-V8's on protein kinase C (PKC) binding and tumor promotion. 8-decylbenzolactone-V8 (6), a new lactone analogue of 8-decylbenzolactam-V8 (4), was synthesized from 2-nitrophenylpyruvic acid (7) in 11 steps. The PKC binding ability and tumor-promoting activities in vitro of 6 were much lower than those of 1 and 4, suggesting that the amide hydrogen of 1 and benzolactam-V8's plays a critical role in tumor promotion, However, it is noteworthy that 6 showed significant selectivity in the PKC isozyme surrogate binding.