345647-41-8

Basic information

• Product Name: C₁₆H₂₆O₃Si
• CAS NO: 345647-41-8
• Molecular Weight: 294.466
• Mol File: 345647-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₆O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₆O₃Si(345647-41-8)
• EPA Substance Registry System: C₁₆H₂₆O₃Si(345647-41-8)

Safety Data

• Hazardous Substances Data: 345647-41-8(Hazardous Substances Data)

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 69-72-7 salicylic acid 
• 114566-88-0 1-triisopropylsilanyl-1H-imidazole 

Downstream Products

• 10021-35-9 2-thioxo-2,3-dihydro-4H-benz[e]-1,3-oxazin-4-one 

Relevant articles and documents

Effective silylation of carboxylic acids under solvent-free conditions with tert-butyldimethylsilyl chloride (TBDMSCL) and triisopropylsilyl chloride (TIPSCL)

Varions types of carboxylic acids can be converted effectively to their corresponding TBDMS and TIPS esters using TBDMSCI and TIPSCI in the presence of imidazole under solvent-free conditions. The advantage of this modified method in comparison with that reported by Corey is the elimination of DMF, which eliminates aqueous work-up. The method is not a time-consuming process and the reactions proceed spontaneously. By this method, absolute chemoselectivity for the protection of carboxylic acid functions in the presence of 2°, 3° hydroxyl groups are observed.