345649-30-1Relevant academic research and scientific papers
Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates
Ryglowski, Artur,Kafarski, Pawel
, p. 10685 - 10692 (1996)
By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.
AMINODIPHOSPHONSAEUREN UND DIAMINODIPHOSPHONSAEUREN - SYNTHESE UND TRANSAMINIERUNGSVERHALTEN
Issleib, K.,Doepfer, K.-P.,Balszuweit, A.
, p. 171 - 178 (2007/10/02)
ω-Phosphonocarbonyl compounds and dicarbonylcompounds react with benzhydrylamine to the corresponding Schiff bases.The latter add diethylphosphite under formation of N-benzhydryl-alkyl-tetraalkyl-phosphonates.Acidolysis with concentrated hydrobromic acid and following treatment with epoxide or ion exchanger gives the title compounds in high yields.The bahavior of aminophosphonic acids under transamination conditions against different substrates and with variable metal ions as catalysts has been investigated.
