345652-60-0Relevant academic research and scientific papers
Addition of Trimethylsilyl Enol Ethers to Isoquinolinium Salts: A Facile Synthesis of 1-(2-Oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)- 1,2-dihydroisoquinolines and Their Cyclization for the Synthesis of the Isoquinoline Alkaloid Skeleton
Akiba, Kin-ya,Nakatani, Masayuki,Wada, Makoto,Yamamoto, Yohsuke
, p. 63 - 68 (2007/10/02)
The addition of trimethylsilyl enol ethers to 2-acylisoquinolinium salts afforded 1-(2-oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)-1,2-dihydroisoquinolines (3) in excellent yields.These compounds were cyclized with bases to give benzoquinolizine derivative
REACTION OF TRIMETHYLSILYL ENOL ETHERS WITH ISOQUINOLINIUM SALTS. A FACILE SYNTHESIS OF ETHYL 1-(2-OXOALKYL)-1,2-DIHYDROISOQUINOLINE-2-CARBOXYLATES AND THEIR CYCLIZATION
Wada, Makoto,Nakatani, Masayuki,Akiba, Kin-ya
, p. 39 - 42 (2007/10/02)
An efficient method is described for the synthesis of ethyl 1-(2-oxoalkyl)-1,2-dihydroisoquinoline-2-carboxylates by C-C bond formation between 2-ethoxycarbonylisoquinolinium chloride and trimethylsilyl enol ethers.The products were treated with a few bases to afford the corresponding pyridoisoquinoline derivatives.
