34570-16-6

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3-AMINO-3-ETHOXYACRYLATE HYDROCHLORIDE is used as a reagent for the synthesis of pyridine carboxamides, which are known as c-Jun NH2-terminal kinase (JNK) inhibitors. These inhibitors play a crucial role in regulating cellular processes such as cell proliferation, apoptosis, and immune responses. By targeting JNK, these compounds have potential applications in the treatment of various diseases, including neurodegenerative disorders, inflammatory conditions, and cancer.
Used in Chemical Synthesis:
ETHYL 3-AMINO-3-ETHOXYACRYLATE HYDROCHLORIDE is also used in chemical synthesis for the production of various compounds with diverse applications. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. ETHYL 3-AMINO-3-ETHOXYACRYLATE HYDROCHLORIDE's versatility allows for the development of new molecules with potential applications in various industries, contributing to the advancement of chemical research and development.

InChI:InChI=1/C7H13NO3.ClH/c1-3-10-6(8)5-7(9)11-4-2;/h5H,3-4,8H2,1-2H3;1H/b6-5-;

Upstream product

• 64-17-5 ethanol 
• 105-56-6 ethyl 2-cyanoacetate 
• 1634-04-4 tert-butyl methyl ether 

Downstream Products

• 852620-86-1 5-amino-2,4-dihydro-2-(4-trifluoromethylphenyl)-3H-pyrazol-3-one 
• 100032-85-7 C₁₃H₁₆ClN₃O₅ 
• 100032-90-4 C₁₃H₁₅ClN₄O₇ 
• 100032-87-9 C₁₃H₁₆BrN₃O₅ 
• 81411-39-4 (Z/E)-3-ethoxy-3-[(2-nitrophenyl)hydrazono]propanoic acid ethyl ester 
• 100032-84-6 C₁₄H₁₉N₃O₅ 
• 309253-64-3 C₁₃H₁₆ClN₃O₅ 
• 100032-88-0 C₁₃H₁₆BrN₃O₅ 
• 848819-92-1 1-(4-chloro-benzyl)-2-ethoxycarbonylmethyl-1H-benzoimidazole-5-carboxylic acid methyl ester 
• 187724-98-7 5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 1260543-99-4 ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate 
• 103095-71-2 5-Amino-1,2-dihydro-1-methyl-2-phenylpyrazol-3-one 
• 114981-06-5 2,4-Bis-(5-cyanomethyl-[1,3,4]oxadiazol-2-yl)-3-(2-hydroxy-phenyl)-pentanedioic acid diethyl ester 
• 114981-02-1 2,4-Bis-(5-cyanomethyl-[1,3,4]oxadiazol-2-yl)-3-phenyl-pentanedioic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives as potential anticancer agents

A series of novel nicotinohydrazide derivatives 6a–g and 1,3,4-oxadiazole functionalized pyridine derivatives 7a–k and 8a–d were prepared in series of steps. All the compounds were screened for cytotoxicity against HeLa (cervical), DU145 (prostate), HepG2

PYRANO-QUINOLINES, PYRANO-QUINOLINONES, COMBINATIONS THEREOF, PHOTOCHROMIC COMPOSITIONS AND ARTICLES

Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring atom and an oxy-substituent at the 5-position ring atom. The pyrano[3,2-c]quinolinone structure is characterized by having a substituted nitrogen atom at the 6-position ring atom and an oxo-substituent at the 5-position ring atom, the nitrogen atom substituents being hydrogen, aliphatic substituents, cycloaliphatic substituents, aromatic substituents, heteroaromatic substituents or a combination thereof. Both of the pyrano[3,2-c]quinoline and pyrano[3,2-c]quinolinone structures are characterized by having two substituents at the 2-position ring atom, each substituent being independently chosen from aliphatic substituents, cycloaliphatic substituents, aromatic substituents, heteroaromatic substituents or a combination thereof, provided that both substituents at the 2-position are not aliphatic. Alternatively, the two substituents at the 2-position can combine to form a spirocyclic group, provided that the spirocyclic group is not norbornylidene or bicyclo[3.3.1]9-nonylidene. The ring atoms have been numbered according to the International Union of Pure and Applied Chemistry rules of nomenclature starting with the 1-position ring atom being the oxygen atom of the pyran ring and numbering counterclockwise therefrom. Also described are photochromic articles that contain or that have coatings or films containing at least one of the novel compositions or combinations thereof with other photochromic materials.

Pyrimidinecarbamate derivatives as intermediates

2,4-Disubstituted 6-[3,6-dihydro-1(2H)-pyridyl]pyrimidine-3-oxides of the formula STR1 wherein R1 is lower alkyl or lower alkoxy-lower alkyl, R2 is hydrogen or --COOR3 wherein R3 is lower alkyl or lower alkoxy-l

80. A New Route to the Synthesis of 2-Amino-6-(methoxycarbonyl)amino-4-(tetrahydropyridyl)pyrimidine 1-Oxide

A new approach to 2-amino-6-(methoxycarbonyl)amino-4-(1,2,3,6-tetrahydro-1-pyridyl)pyrimidine 1-oxide (3) is described.Methyl carbamate (5) reacted with guanidine to the pyrimidinecarbamate 6, which was successively