34572-71-9 Usage
Molecular structure
2,3-dihydropyridazino[4,5-b]quinoxaline-1,4-dione has a complex and specific molecular structure, which includes a combination of pyridazine, quinoxaline, and dione units.
Classification
It belongs to the class of quinoxaline derivatives, which are a group of chemical compounds derived from quinoxaline.
Pharmaceutical research
2,3-dihydropyridazino[4,5-b]quinoxaline-1,4-dione is commonly used in pharmaceutical research as a potential drug candidate due to its unique structure and biological activities.
Therapeutic applications
2,3-dihydropyridazino[4,5-b]quinoxaline-1,4-dione has been studied for its potential therapeutic applications, such as its anti-cancer and anti-inflammatory properties.
Medicinal chemistry interest
Its unique structure and biological activities make it a subject of interest for medicinal chemistry research, with the potential for future development as a novel drug targeting various diseases.
Chemical properties
The chemical properties of 2,3-dihydropyridazino[4,5-b]quinoxaline-1,4-dione and its interactions with biological systems continue to be explored for potential medical advancements.
Check Digit Verification of cas no
The CAS Registry Mumber 34572-71-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,5,7 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34572-71:
(7*3)+(6*4)+(5*5)+(4*7)+(3*2)+(2*7)+(1*1)=119
119 % 10 = 9
So 34572-71-9 is a valid CAS Registry Number.
34572-71-9Relevant academic research and scientific papers
From hit to lead: De novo design based on virtual screening hits of inhibitors of tRNA-guanine transglycosylase, a putative target of shigellosis therapy
Brenk, Ruth,Gerber, Hans-Dieter,Kittendorf, Jeffrey D.,Garcia, George A.,Reuter, Klaus,Klebe, Gerhard
, p. 1435 - 1452 (2007/10/03)
Shigellosis, a bacterial disease, causes the death of more than one million people per year. Extensive studies of Shigella flexneri have recognized tRNA-guanine transglycosylase (TGT, EC 2.4.2.29) as one of the key enzymes involved in the regulation of bacterial virulence. Based on the crystal structure of the Zymomonas mobilis enzyme, we have embarked on the rational design of TGT inhibitors. Herein, we describe the structure-based optimization of hits previously found by virtual screening (see Tables 1-3). For the pteridines, the most potent compound class discovered in a previous virtual screening run, a versatile synthesis could be established giving access to a broad range of substituted derivatives (see Scheme 5). The best ligand in this series, 14, exhibits a Ki = 0.45 μM.
Behaviour of N-benzenesulphonyloxy- and N-acetoxy-2,3-quinoxalinedicarboximides towards some nucleophiles
Youssef, Mohamed Salah Kamel,Abbady, Mohamed Saad
, p. 1671 - 1678 (2007/10/03)
The reactions of N-benzenesulphonyloxy- and N-acetoxy-2,3-quinoxalinedicarboximides with different nucleophilic reagents have been investigated.
