34576-17-5

Upstream product

• 28144-70-9 anthranilic acid amide 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 349135-17-7 N-(2-carbamoylphenyl)-4-chloro-2-nitrobenzamide 

Downstream Products

• 1266584-22-8 N¹-(2-(4-chloro-2-nitrophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine 
• 1266584-24-0 N¹-(2-(2-amino-4-chlorophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine 
• 1266584-26-2 2-chloro-N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)acetamide 
• 1266584-27-3 3-chloro-N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)propanamide 
• 1266584-28-4 4-chloro-N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)butanamide 
• 1266583-94-1 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(piperidin-1-yl)acetamide 
• 1266583-95-2 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(pyrrolidin-1-yl)acetamide 
• 1266583-96-3 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(diethylamino)acetamide 
• 1266583-97-4 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(4-methylpiperazin-1-yl)acetamide 
• 1266583-98-5 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-morpholinoacetamide 
• 1266583-99-6 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(2-(pyrrolidin-1-yl)ethylamino)acetamide 
• 1266584-00-2 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(2-(piperidin-1-yl)ethylamino)acetamide 
• 1266584-01-3 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(3-(dimethylamino)propylamino)acetamide 
• 1266584-02-4 N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-2-(3-(diethylamino)propylamino)acetamide 

Relevant academic research and scientific papers

New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability

To improve the selectivity of indoloquinoline or benzofuroquinoline derivatives, we previously reported several quinazoline derivatives [17]. These compounds could mimic a tetracyclic aromatic system through intramolecular hydrogen bond. Studies showed that these quinazoline derivatives were effective and selective telomeric G-quadruplex ligands. With this encouragement, here we synthesized a series of N-(2-(quinazolin-2-yl)phenyl)benzamide (QPB) compounds as modified quinazoline derivatives. In this modification, a phenyl group was introduced to the aromatic core. The evaluation results showed that part of QPB derivatives had stronger binding ability and better selectivity for telomeric G-quadruplex DNA than LZ-11, the most potential compound of reported quinazoline derivatives. Furthermore, telomerase inhibition of QPB derivatives and their cellular effects were studied.

Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

A series of 2,4-disubstituted quinazoline derivatives found to be a new type of highly selective ligand to bind with telomeric G-quadruplex DNA, and their biological properties were reported for the first time.Their interactions with telomeric G-quadruplex DNA were evaluated by using fluorescence resonance energy transfer (FRET) melting assay, circular dichroism (CD) spectroscopy, surface plasmon resonance (SPR), nuclear magnetic resonance (NMR), and molecular modeling. Our results showed that these derivatives could well recognize G-quadruplex and have high selectivity toward G-quadruplex over duplex DNA. The structure-activity relationships (SARs) study revealed that the disubstitution of quinazoline and the length of the amide side chain were important for its interaction with the G-quadruplex. Furthermore, telomerase inhibition of the quinazoline derivatives and their cellular effects were studied.