34576-82-4

Upstream product

• 14290-91-6 (Z)-3-(4-nitrophenyl)acrylic acid 
• 882-06-4 4-nitro-trans-cinnamic acid 
• 18910-12-8 2-bromo-3-(4-nitro-phenyl)-propionic acid 

Downstream Products

• 1381771-26-1 N-(4-carboxyphenyl)-6-nitro-3-chlorobenzo[b]thiophene-2-carboxamide 
• 1381771-41-0 6-nitro-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride 
• 1381771-36-3 6-nitro-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide 
• 1381771-31-8 N-(4-chlorocarbonylphenyl)-6-nitro-3-chloro-benzo[b]thiophene-2-carboxamide 

Relevant academic research and scientific papers

FC RECEPTOR MODULATING COMPOUNDS AND COMPOSITIONS

The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Synthesis of heterocycles from the products of anionic arylation of unsaturated compounds. 7*. Products of haloarylation of acrylic acid and its esters in the synthesis of benzo[b]thiophene derivatives

3-Chloro-2-chlorocarbonylbenzo[b]thiophenes were obtained on oxidation of Meerwein reaction products, viz. 3-aryl-2-halopropionic acids and their esters, with thionyl chloride in the presence of N-benzyl-N-methylmorpholinium chloride. Disubstituted thioureas were synthesized by the reaction of these compounds with ammonium thiocyanate and aromatic amines, and were cyclized by interaction with iodoacetic acid with the formation of 4-thiazolidinone derivatives. The same cyclization in the presence of aromatic aldehydes leads to the formation of the corresponding 5-arylidene-substituted 4-thiazolidinones.

Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides

An improved process for the preparation of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides is described where a cinnamic acid is converted in the presence of thionyl chloride and a 4-N,N'-disubstituted aminopyridine in one step to the desired product.

Sythesis of substituted Benzothiophenes

Cyclization of the cinnamic acids 1a-t and their derivatives 1u,1v, and 1w with thionyl chloride affords the benzothiophenes 2a-t and 2v,w, respectively. 2a and 2v,w have been also prepared in an independent way from the corresponding alkynes and disulfur dichloride.