34576-94-8 Usage
Uses
Used in Pharmaceutical Industry:
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID is used as an inhibitor for myeloid cell leukemia 1 (Mcl-1) due to its ability to bind with a Ki value of 59 μM. This makes it a potential candidate in the development of treatments for certain types of cancer, as Mcl-1 is known to play a role in the survival and resistance of cancer cells.
Used in Chemical Synthesis:
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID is used as a building block in the synthesis of various inhibitors, such as those targeting the TLR3/dsRNA complex and D-amino acid oxidase (DAO). Its role in these syntheses is crucial for the development of new therapeutic agents and drugs that can potentially treat a range of diseases and conditions.
Used in Research and Development:
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID is also used in research and development for its potential applications in creating new compounds and drugs. Its unique properties and ability to inhibit specific targets make it a valuable tool in the ongoing quest to discover novel therapeutic agents.
References
1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583
2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15
Check Digit Verification of cas no
The CAS Registry Mumber 34576-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,5,7 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 34576-94:
(7*3)+(6*4)+(5*5)+(4*7)+(3*6)+(2*9)+(1*4)=138
138 % 10 = 8
So 34576-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)/p-1
