345893-91-6 Usage
Uses
Used in Pharmaceutical Industry:
SUN B8155 is used as a selective calcitonin receptor agonist for the purpose of lowering serum calcium levels in rats. This application can potentially be translated to human therapeutics for conditions characterized by abnormally high levels of calcium in the blood, such as hyperparathyroidism or certain types of cancer with hypercalcemia.
Additionally, due to its agonistic action on calcitonin receptors, SUN B8155 may have broader applications in the treatment of bone-related disorders, such as osteoporosis, where the modulation of calcium metabolism is crucial for maintaining bone health. Further research would be necessary to explore these potential applications in humans.
Biological Activity
Non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC 50 = 21 μ M). Causes a significant reduction in serum calcium concentrations in vivo following i.p. administration.
Check Digit Verification of cas no
The CAS Registry Mumber 345893-91-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,5,8,9 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 345893-91:
(8*3)+(7*4)+(6*5)+(5*8)+(4*9)+(3*3)+(2*9)+(1*1)=186
186 % 10 = 6
So 345893-91-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H15N3O3/c1-8-7-12(18)17(20)14(19)13(8)9(2)16-11-6-4-3-5-10(11)15/h3-7,19-20H,15H2,1-2H3/b16-9+
345893-91-6Relevant academic research and scientific papers
Chen, Xin,Gong, Zheng,Guo, Shengchao,Jia, Yingli,Jiang, Xinyu,Shi, Li,Sun, Jinpeng,Wang, Yaomin,Xu, Liwei,Yang, Chan,Yu, Xiao,Zhang, Yan,Zhao, Shuai
, (2020)
The natural calcitonin (CT) receptor and its peptide agonists are considered validated targets for drug discovery. A small molecule agonist, SUN-B8155, has previously been shown to efficiently activate cellular CTR. Herein, we report the synthesis of a se
