345907-99-5Relevant articles and documents
Rhodium-catalyzed asymmetric arylation of α,β-unsaturated imines with arylstannanes. Catalytic asymmetric synthesis of allylic amines
Hayashi, Tamio,Ishigedani, Mitsuo
, p. 2589 - 2595 (2001)
Catalytic asymmetric arylation of N-alkylidenesulfonamides 1a-d, which are prepared from α,β-unsaturated aldehydes and 4-nitrobenzenesulfonamide, with aryltrimethylstannanes 2m-p proceeded in the presence of 3 mol% of a rhodium catalyst coordinated with (R)-MOP ligand in dioxane at 110°C to give sulfonamide of allylic amines (R)-3 with high enantioselectivity (up to 96% ee) in high yields. Some of the allylic amines were converted in to the sulfonamide of (S)-phenylglycine without loss of enantiomeric purity by oxidative cleavage of the carbon-carbon double bond.
