345911-52-6

Basic information

• Product Name: (R)-4,4-dimethoxy-5-ethylcyclohex-2-enone
• Synonyms: (R)-4,4-dimethoxy-5-ethylcyclohex-2-enone
• CAS NO: 345911-52-6
• Molecular Weight: 184.235
• Mol File: 345911-52-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4,4-dimethoxy-5-ethylcyclohex-2-enone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4,4-dimethoxy-5-ethylcyclohex-2-enone(345911-52-6)
• EPA Substance Registry System: (R)-4,4-dimethoxy-5-ethylcyclohex-2-enone(345911-52-6)

Safety Data

• Hazardous Substances Data: 345911-52-6(Hazardous Substances Data)

Upstream product

• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 557-20-0 diethylzinc 

Downstream Products

• 479544-01-9 (+)-trans-3,5-diethyl-4,4-dimethoxycyclohexanone 
• 479544-04-2 (-)-trans-2,6-diethyl-4-methylenecyclohexanone 

Relevant articles and documents

A catalytic enantioselective route to cis- and trans-3,4,4,5-tetrasubstituted cyclohexanones; remarkable chiral catalyst control in sequential catalytic 1,4-additions to cyclohexadienones

Asymmetric copper-phosphoramidite catalysed conjugate addition of Et2Zn to easily accessible, nearly enantiomerically pure cyclohexenones 2 and 4 was performed. Depending on the enantiomer of the chiral phosphoramidite used, the cis- or trans-3,4,4,5-tetrasubstituted cyclohexanones 5 and 6 could be formed selectively. Surprisingly, there is no directing effect of the 5-ethyl- or 4-alkoxy-substituents and the stereochemical outcome is only governed by the configuration of the chiral ligand.