345912-43-8

Basic information

• Product Name: 3-amino-4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
• Synonyms: 3-amino-4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
• CAS NO: 345912-43-8
• Molecular Formula: C₂₃H₁₈ClN₃OS
• Molecular Weight: 419.92652
• Mol File: 345912-43-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide(345912-43-8)
• EPA Substance Registry System: 3-amino-4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide(345912-43-8)

Safety Data

• Hazardous Substances Data: 345912-43-8(Hazardous Substances Data)

Upstream product

• 587-65-5 N-chloroacetyl-aniline 
• 83236-50-4 4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione 
• 345912-31-4 2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-phenyl-acetamide 
• 134791-44-9 (E)-2-(4-chlorobenzylidene)cyclopentan-1-one 

Relevant articles and documents

Synthesis of some new thieno[2,3-b]pyridines, pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidines and pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]-triazines

4-Aryl-3-cyano-2-substituted-methylthiocyclopenta[b]pyridines (3a-c and 4a-i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones(2a-c) with chloroacetonitrile or chloro-N-arylacelamides, respectively. On treatment of these products with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to afford the corresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyridines (5a-c and 6a-i). Most of the latter thienopyridines were used as synthons for the target cyclopenta[5′,6′]pyrido[3′,2′:4,5]thieno[3,2-d] pyrimidines and cyclopenta[5′,6′] pyrido[3′,2′:4,5]thieno[3,2-d)[1,2,3]triazines.