345948-98-3

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 2650-14-8 3-bromo-4-hydroxycoumarin 

Downstream Products

• 942120-70-9 3-bromo-4-(2-bromophenylsulfanyl)-coumarin 
• 942120-72-1 C₁₅H₈BrClO₂S 
• 942120-71-0 3-bromo-4-phenylsulfanyl-coumarin 
• 71644-60-5 3,4-diphenyl-2H-1-benzopyran-2-one 
• 7622-75-5 2-oxo-3-phenyl-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 952202-82-3 2-oxo-3-(p-tolyl)-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 952202-83-4 3-(4-methoxyphenyl)-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Convenient Michael addition/β-elimination approach to the synthesis of 4-benzyl- and 4-aryl-selenyl coumarins using diselenides as selenium sources

A concise and efficient, two-step approach toward 4-organoselenyl coumarin derivatives from the easily available 4-hydroxycoumarins, is reported. The synthesis was based on conventional tosylation followed by a tandem selena-Michael addition/β-elimination reaction of an aryl-/benzyl-selenolate anion on the corresponding 4-tosyloxycoumarins. The selenolate anions were conveniently generated in situ by exposure of the corresponding diselenides to NaBH4. Selected compounds demonstrated to exhibit antioxidant properties in mice cortex and hippocampus.

General and efficient route for the synthesis of 3,4-disubstituted coumarins via Pd-catalyzed site-selective cross-coupling reactions

(Chemical Equation Presented) Palladium-catalyzed site-selective cross-coupling reactions of 3-bromo-4-trifloxycoumarin or 3-bromo-4- tosyloxycoumarin provide an efficient and facile route for the synthesis of 3,4-disubstituted coumarins, which include 3,

A general and efficient route to 3-amino-4-sulfanylcoumarins via substitution and palladium-catalyzed amination of 3-bromo-4-tosyloxycoumarins

A highly efficient and practical route to 3-amino-4-sulfanylcoumarins from 3-bromo-4-tosyloxy-coumarins via substitution and palladium catalyzed amination reactions is described.