34596-27-5

Upstream product

• 106-96-7 propargyl bromide 
• 123-31-9 hydroquinone 
• 107-19-7 propargyl alcohol 
• 106-51-4 p-benzoquinone 
• 624-65-7 2-propynyl chloride 
• 80-05-7 BPA 
• 901142-40-3 1,2-dibromo-3-(4-trifluoromethanesulfonyloxyphenyloxy)propane 
• 6903-14-6 1-(benzyloxy)-4-(prop-2-yn-1-yloxy)benzene 

Downstream Products

• 139139-72-3 4-methoxy-4-(prop-2-yn-1-yloxy)cyclohexa-2,5-dien-1-one 
• 350795-99-2 1,6-bis(4-hydroxyphenoxy)hexa-2,4-diyne 
• 847144-55-2 1-but-3-enyloxy-4-prop-2-ynyloxy-benzene 
• 847144-69-8 acrylic acid 4-prop-2-ynyloxy-phenyl ester 
• 34596-31-1 1-[(3-methyl-2-butenyl)oxy]-4-propargyloxybenzene 
• 1233250-97-9 C₄₄H₄₂N₃O₁₂P₃ 
• 1233250-88-8 C₅₄H₄₂N₃O₁₂P₃ 
• 1418130-91-2 N,N’-bis-propargyl-1,6,7,12-tetra-(4-propargyloxyphenoxy)perylene-3,4,9,10-tetracarboxylic diimide 
• 1415048-51-9 N,N'-bis-(2,6-diisopropylphenyl)-1,6,7,12-tetra-(4-prop-2-ynyloxy-phenoxy)perylene-3,4:9,10-tetracarboxydiimide 

Relevant academic research and scientific papers

A dual-responsive hyperbranched supramolecular polymer constructed by cooperative host-guest recognition and hydrogen-bond interactions

A homotritopic pillar[5]arene (H3) containing adenine units was synthesized and employed to interact with a uracil derivative (6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanenitrile, G) to form a hyperbranched supramolecular polymer. The hype

Synthesis and thermoresponsive properties of OEGylated polypeptide with a LCST at body temperature in water and with a UCST in alcohol or ethanol/water solvent mixture

Thermoresponsive polypeptides bearing oligo(ethylene glycol) (OEG) pendants (i.e., P1-OEGx and P2-OEGx, x = 3, 7) were synthesized by copper-mediated 1,3-dipolar cycloaddition with high grafting efficiency (≥97%) between side-chain “clickable” polypeptides, namely poly(γ-4-(propargoxycarbonyl)benzyl-l-glutamate) (P1) or poly(γ-4-(4-propargoxyphenoxycarbonyl)benzyl-l-glutamate) (P2) and azido functionalized OEG (N3-OEGx). P1 and P2 with similar degree of polymerization (DP = 35 or 37) were prepared from triethylamine initiated ring-opening polymerization of respective N-carboxyanhydrides. P1-OEGx (x = 3, 7) and P2-OEG7 showed reversible UCST-type phase transitions in various alcoholic solvents (e.g., ethanol, propanol, n-butanol, and n-pentanol). P2-OEG3 also showed reversible UCST-type phase transitions in ethanol/water solvent mixtures at the weight percentage of ethanol no less than 50 wt %. P1-OEG7 and P2-OEG7 showed reversible LCST-type phase transitions in aqueous solutions. Variable-temperature UV–vis spectroscopy revealed that the LCST-type phase transition temperature (Tpt) of P2-OEG7 with benzoic acid phenyl ester linkages was at around body temperature and it was barely changed with the variation of polymer concentration, yet it showed noticeable dependence on the nature of salt (i.e., NaCl, NaBr, NaI, or KCl) and salt concentration in the range of 0–300 mM.

A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain

Herein, an electrochemical method for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain was reported. Using this tool, it was found that MAO-A increased Ca2+entry into neuronsviathe TPRM2 channel in the live mouse brain of an AD model.

Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. Here, we have performed a cysteine-reactive covalent ligand screen to identify compoun

Design, Synthesis, and Evaluation of Novel L-Pyroglutamic Acid Derivatives as Potent Antifungal Agents

A series of novel L-pyroglutamate containing 1,2,3-triazole ring substructures was synthesized and characterized by adopting an appropriate synthetic scheme. The effect of different substituents on the triazole ring at the ortho-, meta- and para-positions

Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition

A facile and convergent procedure for the synthesis of azobenzene-based probe was reported, which could selectively release interested proteins conducted with sodium dithionite. Besides, the cleavage efficiency is closely associated with the structural features, in which an ortho-hydroxyl substituent is necessary for reactivity. In addition, the azobenzene tag applied in the Ac4GlcNAz-labled proteins demonstrated high efficiency and selectivity in comparison with Biotin-PEG4-Alkyne, which provides a useful platform for enrichment of any desired bioorthogonal proteomics.

Click synthesis and complexation properties of a new unsymmetrical macrocycle bearing 1,4-dioxabenzene and triazole units

We report herein synthesis of a new triazole-based unsymmetrical macrocycle through Copper(I) catalyzed Alkyne - Azide Cycloadditon (CuAAC), using a copper(I)-N-heterocyclic carbene complex as catalyst. The obtained macrocycle was characterized by NMR spectroscopy and High Resolution Mass Spectrometry (HRMS). The complexation ability of the macrocycle towards various cations as well as its selectivity for a particular metal-ion was investigated by HRMS experiments.

Preparation method of fluorescein isothiocyanate derivative

The invention provides a preparation method of a novel fluorescein isothiocyanate derivative. The fluorescein isothiocyanate derivative prepared by the method can be directly connected with amino acidin a biological material, so that biomolecules marked by the fluorescein isothiocyanate derivative are formed, and the detection of the biological material is further realized.

Preparation method of fluorescein isothiocyanate derivative

The invention provides a preparation method of a novel fluorescein isothiocyanate derivative. The fluorescein isothiocyanate derivative prepared by the method can be directly connected with amino acidin a biological material, so that biomolecules marked by the fluorescein isothiocyanate derivative are formed, and the detection of the biological material is further realized.

Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA

Divalent ligands were prepared as inhibitors for the adhesion protein of the problematic Pseudomonas aeruginosa pathogen. Bridging two binding sites enables simultaneous binding of two galactose moieties, which strongly enhances binding. An alternating motif of glucose and triazole and aryl groups was shown to have the right mix of rigidity, solubility, and ease of synthesis. Spacers were varied with respect to the core unit as well as the aglycon portions in an attempt to optimize dynamics and enhance interactions with the protein. Affinities of the divalent ligands were measured by ITC, and Kd's as low as 12 nM were determined, notably for a compounds with either a rigid (phenyl) or flexible (butyl) unit at the core. Introducing a phenyl aglycon moiety next to the galactoside ligands on both termini did indeed lead to a higher enthalpy of binding, which was more than compensated by entropic costs. The results are discussed in terms of thermodynamics and theoretical calculations of the expected and observed multivalency effects.