3460-25-1

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-3,4,5-tribromobenzene is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-CHLORO-3,4,5-TRIBROMOBENZENE serves as an intermediate for the production of pesticides and other agrochemicals, contributing to the development of effective solutions for crop protection and management.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1-CHLORO-3,4,5-TRIBROMOBENZENE is utilized for the preparation of various organic compounds. Its reactive nature facilitates multiple chemical reactions, leading to the formation of a wide range of products.
Used in Specialty Chemicals Production:
1-Chloro-3,4,5-tribromobenzene also acts as a building block in the creation of specialty chemicals. Its incorporation into these chemicals can enhance their properties and performance in specific applications.
It is crucial to handle 1-CHLORO-3,4,5-TRIBROMOBENZENE with care due to its hazardous nature and potential health risks, ensuring safety in its application across different industries.

InChI:InChI=1/C6H2Br3Cl/c7-4-1-3(10)2-5(8)6(4)9/h1-2H

Upstream product

• 106-47-8 4-chloro-aniline 

Relevant academic research and scientific papers

Alkyl Nitrite-Metal Halide Deamination Reactions. 7. Synthetic Coupling of Electrophilic Bromination with Substitutive Deamination for Selective Synthesis of Multiply Brominated Aromatic Compounds from Arylamines

Aromatic amines undergo substitution with copper(II)bromide that is in competition with substitutive deamination when these reactions are performed with tert-butyl nitrite.Except for the exceptionally reactive 4-substituted 1-aminonaphthalenes,which undergo selective bromine substitution at the 1- and 2-positions in relatively high isolated yields,rates for oxidative bromination and substitutive deamination are not sufficiently different that selective multiple bromination can be achieved.Oxidative bromination of N,N-dimethylaniline by copper(II)bromide occurs with partial dealkylation,and nitration products are observed from reactions performed with copper(II)bromide and tert-butyl nitrite.Implications of these results for the successful utilization of copper(II)bromide/tert-butyl nitrite combinations in substitutive deamination reactions of aromatic amines are discussed.Multiply brominated aromatic compounds are produced from aromatic amines in high yield through treatment of the aromatic amine with the combination of molecular bromine and catalytic quantities of copper(II)bromide and,following a normally brief time delay,with tert-butyl nitrite.All unsubstituted aromatic ring positions ortho and para to the amino group,as well as the position of the amino group,are substituted by bromine.The only observed byproducts from use of this procedure (usually 2percent yield) are the partially brominated benzene derivatives.